Christian McCaffrey injures knee, will not return vs. Bills

11:30 p.m. update: 49ers coach Kyle Shanahan says in postgame press conference that McCaffrey suffered a potentially season-ending PCL injury.

9:50 p.m. update: The 49ers announced McCaffrey won’t return during the game due to the knee injury.

9:05 p.m. update: The 49ers have announced McCaffrey is questionable to return due to a knee injury.

9:02 p.m. update: McCaffrey walked back to the locker room with the 49ers trainer. He was able to walk without assistance, but his status is uncertain.

The San Francisco 49ers have received some kind of scare in the second quarter against the Buffalo Bills. Running back Christian McCaffrey took a pitch and quickly slid down to the field for a five yard loss. He quickly hobbled off the field after the play. On the replay, he was quickly gimpy as he caught the pitch and started running.

McCaffrey left the game with 53 rushing yards and 14 receiving yards. He has gone into the injury tent. More to come.