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Maybe You’ve Been Making Light Roast Espresso Wrong

Maybe You’ve Been Making Light Roast Espresso Wrong

“You need to realize you’ve already rejected tradition by not getting a dark roast coffee. You’ve embraced modernism,” Hedrick says. “And if you’re going to embrace modernism and reject traditionalism, you must always also reject traditional shot parameters.”

But terrific light roast is possible. There are two ways to go.

You can go traditional—changing your dose and ratios a bit but aiming for a cup with intensity and balance. That’s what I’ve been honing for the past year.

But there’s also a wilder, weirder path: The turbo shot, also called a gusher. Hedrick, following the results of new scientific research from University of Oregon biochemistry professor Christopher Hendon and others, has gone all in on throwing out the entire traditional espresso rulebook in his pursuit of light roast espresso that’s neither sour nor bitter.

Here are two ways of making light roast espresso, and the results.

How to Make a “Traditional” Light Espresso Shot

Some of the knee-jerk advice for light roast espresso was just to keep grinding finer and finer and jack up the temperature on your machine in order to get better extraction.

Problem is, the finer you grind, the more likely you’ll choke your machine. And also the more likely that water will clog up in places and find a path of least resistance through your coffee puck. Which is to say, it’ll “channel” through only some of the coffee, extracting too much from some parts of your coffee puck while under-extracting from other parts. The results will be intense, bitter, and sour. It’ll taste like those early light roast espressos that put me off of light roast espresso.

There’s a different path.

Instead of pretending light roast is dark roast and going finer and finer, you can instead adjust the amount of coffee and water. Use more coffee and pull longer, for more time—and grind fine but not ridiculously fine.

This was the approach used on a recent visit to Sterling Coffee Roasters, one of the few Portland, Oregon, roasters I’ve found that regularly (and expertly) pulls light roast espresso shots. The shop offered up an excellent, cranberry-fruity light roast Ethiopia Bensa Bombe using this method. My barista let a two-ounce shot drag out for 37 seconds until its fruity-acidic flavors mixed with a little bit of backbone, not to mention the flavors of ferment resulting from natural-process beans.

Photograph: Matthew Korfhage

This is the classic approach I’ve arrived at through trial and error, a bit of research, and a lot of conversation with smart baristas:

  • Increase the amount of coffee you use. A darker-roast double shot is often 15 or 18 grams. But going bigger, about 20 grams, can extend the extraction time without having to grind so fine you choke your machine.
  • Increase the water-to-coffee ratio. Standard espresso is a 1:2 ratio. That means if you use 15 grams of espresso, you’ll aim for 30 grams of espresso in your cup. Longer ratios, often called “lungo,” will also help increase extraction by simply running more water through a certain volume of coffee. I often go as long as 1:3, which is about 60 grams (two ounces) for a 20-gram espresso shot.
  • Go a little longer. It’s a long shot, and a lot of coffee. Don’t worry about the “25 to 30 seconds” you’ve been told is the only way to go. Drift a little longer, maybe into the mid-30s or so. You may find a more balanced shot by the end of it.
How to Make Light Roast Espresso According to Chemists

Photograph: Matthew Korfhage

  • Grind only as finely as you need to, but don’t go crazy. Longer shots, and thicker pucks, will offer resistance to the flow of water, without needing powder-fine espresso dust that ends up creating more unpredictable results.
  • Spritz your beans. A recent paper by authors including Hendon showed that there’s real science behind the idea that spritzing water on coffee beans can help reduce static electricity and clumping, leading to more even extraction.
  • Look for natural-process beans, not washed. Most modern beans, until recently, were “washed,” which removes all of the coffee fruit before processing, leading to a more predictable result. But lately, a lot of growers in Latin America and Africa have begun to try out natural process beans, fermenting some of the coffee berry sugars or mucilage. Natural processing, or honey and bourbon processing, can lead to more body, more sweetness, and more complexity. It can also lead to less acidity. The result, in light roast espresso, is coffee that’s not just more balanced but more nuanced, with added earthy notes that can bind the coffee’s flavors into a more organic whole.
  • Use a grinder well-attuned to light roast espresso. Some geometries are better attuned to light-roast beans than others, notes coffee expert Hedrick, largely because light roast beans grind less easily. Hexagonal or pentagonal geometries, with more “points” on the conical burr, tend to have better results. Assuming you’re not on a huge budget, Hedrick recommends the Kingrinder K6 manual grinder that’s also recommended by WIRED. I’ve been using it for months, with good results, to make light roast espresso.
Kingrinder K5, a manual coffee grinder composed of a cylindrical container and a handheld crank

Photograph: Matthew Korfhage

Kingrinder

K6 Manual Coffee Grinder

How to Make a Turbo Espresso Shot, or “Gusher”

Here’s the new-school approach laid out by coffee expert Lance Hedrick, following new findings published in 2020 by coffee scientist Christopher Hendon at the University of Oregon, among others. The turbo espresso shot, also called a gusher, involves up-ending pretty much every assumption about how good espresso is made—grinding coarser for light roast espresso and running a whole lot of water through the puck quickly and at lower pressure.

The result is a fully extracted shot, sometimes even better extracted than a classic one. But the flavor is different: It tends to be sweeter, aromatic, and almost devoid of bitterness.

Crazy, right? Not really. There’s a bit of science behind it, which you can read about in the bottom section of the article. But first, here’s how to make a turbo shot, according to advice from coffee expert Hedrick, who says the best shots he’s pulled all come from this method.

  • Use less beans by volume. Try out a 15-gram double shot to better facilitate flow of water through the puck.
  • Grind coarser. In my own attempts to replicate Hedrick’s method, I’ve found that you need a coarseness a lot closer to the coarsest espresso.
  • Use a high ratio. Try out up to a 1:3 ratio, meaning 45 grams of espresso for 15 grams of coffee.
  • Let it gush. The resulting fast flow will knock out a big shot in 10 to 15 seconds or so, way faster than any traditional espresso.
  • Don’t worry about crema. You’re not going to get the same stable crema you’ll get from robusta-dark-roast Italian beans on traditional methods. But crema is not the most important part of your espresso, and less important to mouthfeel and body than many assume. “Don’t worship crema,” Hedrick says. “In fact, crema is the most bitter part of your espresso.”
  • Don’t neglect your water. Good water means good extraction. Filter your water, of course, which will help keep your machine running longer. But also? Throw a little baking soda in the tank, if you’ve got soft water, and it’ll help reduce the acidity of your espresso.
  • First, adjust yield. Then grind size. Don’t play with your grind first. If your coffee is sour, try running the shot to a higher volume. If bitter, dial it back. You can get more consistent results playing with yield than with grind. (Though, you may also need to adjust your grind.)
  • OK, the pressure thing. Hendon’s research showed best extraction on a turbo shot with 6 bars of pressure, which helps slow water’s path through the puck. But unless you do some modding or hacks on your espresso machine, you probably have a machine designed to pump 9 bars. Is it all for nought? According to Hedrick, it’s probably kinda fine, even if you don’t have a machine that can program lower pressure. With a coarse grind, a fast shot, and fewer grounds, you likely won’t build up 9 bars anyway. Just roll with what tastes good.

The Theory Behind Turbo Espresso Shots

OK, so how does a turbo shot work?

A gusher is exactly what it sounds like. It’s an espresso shot that practically just pours out of the portafilter so it’s over in about 15 seconds, even at high volume—a heresy among traditional espresso people. Conventional wisdom says this shot should taste terrible, underextracted, sour. But magically, it doesn’t. Extraction is in some ways better and more reliable.

How to Make Light Roast Espresso According to Chemists

Photograph: Matthew Korfhage

A turbo shot tastes … kinda sweet, actually.

The idea isn’t just maverick. It’s backed by science. Back in 2020, a few researchers, including University of Oregon chemistry professor Christopher Hendon and Australian barista Michael Cameron, published a research paper that used mathematical modeling to show that a lot of what people had assumed about espresso was just kinda untrue.

Finer grinds don’t necessarily or always mean better extraction, they showed. And the 25-second espresso shot is a tradition … not a scientific certainty. Often, a lot of the unpleasant flavor compounds start to emerge after a mere 20 seconds. But especially, Hendon tells WIRED, grinding more coarsely, and using lower pressure and lower volumes of beans, leads to much more consistency between shots.

“What we were trying to do is find brew parameters that would allow us to make highly reproducible espresso,” he said. What he and his collaborators learned was that if you grind finer, extraction got better, but not forever. At some “critical point,” grinding finer actually led to worse extraction. Coffee clumped up. It clogged. Water actually got less contact with coffee grounds, not more.

If you ground beans more coarsely, and let the water flow longer through lower volumes of beans, you could get more even extraction, they discovered after analysis. This method also offered more repeatability. Using less coffee, and lower pressure, likewise allowed water to spend more time in contact with the coffee grounds—leading to even better extraction.

How to Make Light Roast Espresso According to Chemists

Photograph: Matthew Korfhage

And so, grind coarser. Use less coffee. Use less pressure. Let it gush. Result: excellent extraction of sweet and aromatic compounds. Almost no bitterness. Hedrick tells WIRED that the best shots he’s pulled in recent memory have come using this method.

Hendon figures few would have paid attention to his findings if Hedrick hadn’t taken up the research and run with it—making video after video about the new technique for making what Hedrick now calls “modern” espresso, highlighting a bean’s bright aromatics without all the bitterness. Traditional shots just don’t get the flavors Hedrick wants, and have too many of the bitter flavors he hates.

Now, in the meantime, there are caveats. Hendon published a more recent paper showing that clumping at finer grinds could be avoided if you just spritzed your beans with a bit of water before grinding. (Coffee nerds had been doing this for a while; it just hadn’t been backed up by science.)

Which is to say, while turbo shots are a new and interesting and fun discovery, classic light roast espresso shots can also get good results.

Which Is Better, Classic Light Roast Espresso or Modern Turbo Shots?

Classic light roast espresso shots and turbo shots are both achievable. But note that turbo shots are a lot easier to pull off: Coarser grinds are quite simply more manageable. You’ll get more consistent shots time after time with gushers, Hedrick and Hendon both note.

So, how does a turbo shot taste? It is, on my attempts over the past couple of weeks, not quite as complex as more traditional, longer, finer-ground shots—at least when I’ve attempted them with more traditional 9-bar machines, like the Breville Oracle Jet and the new Meraki espresso machine I’m currently testing.

The combination of coarse grind and fast flow actually end up reminding me somewhat of results from some newer superautomatic espresso machines like the excellent De’Longhi Rivelia. These machines grind coarser and flow faster, and smooth out the edges of traditional shots. The results on my turbo shots were likewise smooth and flavorful, and a bit more sweet, but maybe also a less exciting and eventful ride.

  • Image may contain: Device, Appliance, Electrical Device, Mixer, and Cup
  • Image may contain: Cup, Beverage, Coffee, Coffee Cup, and Espresso

    Photograph: De’Longhi

  • Image may contain: Cup, Beverage, Coffee, and Coffee Cup

    Photograph: Matthew Korfhage

  • Image may contain: Cup

    Photograph: Matthew Korfhage

This said, I’ve also struck intense flavor gold with some turbo shots. And when they were good, the results were shockingly good. I have drunk a 12-second light roast espresso with flavor so round and full it made me question everything I’d previously been told about how good espresso should be made.

The difference between turbo and classic light roast shots is actually, if I’m comparing, a lot like the difference between a new-school hazy IPA and a West Coast IPA. The turbo shot, like a modern hazy IPA, offers more juiciness and less bitterness. Maybe it also offers a little less complexity. But in exchange, it’s an easy, smooth ride across the palate that’s more in line with modern tastes. It’s delicious.

So which do you prefer? Juicy or balanced? Complexity and intensity, or affable aroma and sweetness? A difficult test of espresso mettle, or an easy win? Shoot your shot.

Meet the Experts

  • Lance Hedrick is one of the most-followed coffee industry voices on YouTube, a two-time World Latte Art champion, two-time US Brewers Cup finalist, and director of EU and West Coast wholesale for Onyx Coffee.
  • Christopher Hendon is associate professor of computational materials chemistry at the University of Oregon and has authored or coauthored numerous published works on the chemistry of coffee flavor and extraction.

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#Youve #Making #Light #Roast #Espresso #Wrong

published late last week in the journal Nature Microbiology.

Good guy prions?

Prions are some of the strangest things around. They’re the misfolded form of a protein naturally found in the body. When a prion comes across its “normal” counterpart, it can somehow induce the latter to turn into a prion itself, almost like a zombie infection.

Classic prion disorders like mad cow disease and Creutzfeldt-Jakob disease are caused by the steady accumulation of one particular type of protein, aptly named the prion protein; these disorders are universally fatal. Some scientists have also argued that other neurodegenerative conditions, such as Alzheimer’s disease, are caused by other kinds of misfolded proteins that act in a similar way to prions.

According to the study researchers, there’s growing evidence that prions and prion-like proteins are more than just harbingers of death. Studies have found that the normal prion protein and the prion-like amyloid beta (one of the drivers of Alzheimer’s) can have antimicrobial activity, for instance. So the team decided to conduct a sweeping analysis looking for antimicrobial peptide fragments within these proteins.

The researchers had previously built an AI model intended to predict the antimicrobial activity of any given peptide fragment, named APEX 1.1. Then they let APEX scan through 19.3 million short peptide fragments found in 2,897 prion and prion-like proteins. They initially uncovered 1,179 candidates, which the team narrowed down to 75 that showed the most potential. Of these, 59 were able to inhibit the growth of at least one bacterial germ in the lab, including 42 that did so at low levels (important for dosing considerations).

Finally, the researchers tested two of the strongest candidates on the skin of mice infected with Acinetobacter baumannii, a common source of drug-resistant infections in people. The candidates appeared to be roughly as effective as polymyxin B, an existing antibiotic often used as a last resort drug for certain drug-resistant infections.

The researchers have coined these antibacterial fragments collected from prions as “prionins.”

The future of prionins

More research is obviously needed to verify whether the team’s prionins can actually work as hoped—and safely—in people. The researchers also note their findings don’t settle the open question as to whether prions or prion-like proteins naturally tackle bacterial infections in our body.

At the same time, they do argue their work provides a strong proof of concept that prionins identified through AI can be viable antibiotic candidates for further testing.

“For a long time, drug discovery has been limited not only by what we can test, but by where we choose to look,” said senior study author César de la Fuente, director of the Machine Biology Group at the University of Pennsylvania Perelman School of Medicine, in a statement from the university. “AI is changing that. It gives us a way to search the hidden layers of biology and ask whether molecules associated with one story—in this case, disease—may also carry another story with therapeutic potential.”

With any luck, the proteins known for causing the scariest diseases around could someday turn into our antibacterial allies.

#Deadly #Proteins #Mad #Cow #Disease #Fight #Superbugsantibiotic resistance,experimental drugs,prions">Deadly Proteins Behind Mad Cow Disease Might Help Us Fight Superbugs
                The next frontier of antibiotics might come from an unexpected place. Recent research identifies potential antibiotic candidates from inside prions—proteins capable of causing some of the deadliest brain infections ever known, such as mad cow disease.

 Scientists at the University of Pennsylvania used artificial intelligence to rapidly search hundreds of prions and prion-like proteins for peptides with antibacterial activity. They found several dozen promising candidates, two of which have already shown results treating bacterial infections in mice. The team’s findings establish “prion-related proteins as a productive source space for antibiotic discovery,” the scientists wrote in their paper, published late last week in the journal Nature Microbiology.

 Good guy prions? Prions are some of the strangest things around. They’re the misfolded form of a protein naturally found in the body. When a prion comes across its “normal” counterpart, it can somehow induce the latter to turn into a prion itself, almost like a zombie infection.

 Classic prion disorders like mad cow disease and Creutzfeldt-Jakob disease are caused by the steady accumulation of one particular type of protein, aptly named the prion protein; these disorders are universally fatal. Some scientists have also argued that other neurodegenerative conditions, such as Alzheimer’s disease, are caused by other kinds of misfolded proteins that act in a similar way to prions.   According to the study researchers, there’s growing evidence that prions and prion-like proteins are more than just harbingers of death. Studies have found that the normal prion protein and the prion-like amyloid beta (one of the drivers of Alzheimer’s) can have antimicrobial activity, for instance. So the team decided to conduct a sweeping analysis looking for antimicrobial peptide fragments within these proteins.

 The researchers had previously built an AI model intended to predict the antimicrobial activity of any given peptide fragment, named APEX 1.1. Then they let APEX scan through 19.3 million short peptide fragments found in 2,897 prion and prion-like proteins. They initially uncovered 1,179 candidates, which the team narrowed down to 75 that showed the most potential. Of these, 59 were able to inhibit the growth of at least one bacterial germ in the lab, including 42 that did so at low levels (important for dosing considerations). Finally, the researchers tested two of the strongest candidates on the skin of mice infected with Acinetobacter baumannii, a common source of drug-resistant infections in people. The candidates appeared to be roughly as effective as polymyxin B, an existing antibiotic often used as a last resort drug for certain drug-resistant infections. The researchers have coined these antibacterial fragments collected from prions as “prionins.”

 The future of prionins More research is obviously needed to verify whether the team’s prionins can actually work as hoped—and safely—in people. The researchers also note their findings don’t settle the open question as to whether prions or prion-like proteins naturally tackle bacterial infections in our body. At the same time, they do argue their work provides a strong proof of concept that prionins identified through AI can be viable antibiotic candidates for further testing. “For a long time, drug discovery has been limited not only by what we can test, but by where we choose to look,” said senior study author César de la Fuente, director of the Machine Biology Group at the University of Pennsylvania Perelman School of Medicine, in a statement from the university. “AI is changing that. It gives us a way to search the hidden layers of biology and ask whether molecules associated with one story—in this case, disease—may also carry another story with therapeutic potential.”

 With any luck, the proteins known for causing the scariest diseases around could someday turn into our antibacterial allies.      #Deadly #Proteins #Mad #Cow #Disease #Fight #Superbugsantibiotic resistance,experimental drugs,prions

published late last week in the journal Nature Microbiology.

Good guy prions?

Prions are some of the strangest things around. They’re the misfolded form of a protein naturally found in the body. When a prion comes across its “normal” counterpart, it can somehow induce the latter to turn into a prion itself, almost like a zombie infection.

Classic prion disorders like mad cow disease and Creutzfeldt-Jakob disease are caused by the steady accumulation of one particular type of protein, aptly named the prion protein; these disorders are universally fatal. Some scientists have also argued that other neurodegenerative conditions, such as Alzheimer’s disease, are caused by other kinds of misfolded proteins that act in a similar way to prions.

According to the study researchers, there’s growing evidence that prions and prion-like proteins are more than just harbingers of death. Studies have found that the normal prion protein and the prion-like amyloid beta (one of the drivers of Alzheimer’s) can have antimicrobial activity, for instance. So the team decided to conduct a sweeping analysis looking for antimicrobial peptide fragments within these proteins.

The researchers had previously built an AI model intended to predict the antimicrobial activity of any given peptide fragment, named APEX 1.1. Then they let APEX scan through 19.3 million short peptide fragments found in 2,897 prion and prion-like proteins. They initially uncovered 1,179 candidates, which the team narrowed down to 75 that showed the most potential. Of these, 59 were able to inhibit the growth of at least one bacterial germ in the lab, including 42 that did so at low levels (important for dosing considerations).

Finally, the researchers tested two of the strongest candidates on the skin of mice infected with Acinetobacter baumannii, a common source of drug-resistant infections in people. The candidates appeared to be roughly as effective as polymyxin B, an existing antibiotic often used as a last resort drug for certain drug-resistant infections.

The researchers have coined these antibacterial fragments collected from prions as “prionins.”

The future of prionins

More research is obviously needed to verify whether the team’s prionins can actually work as hoped—and safely—in people. The researchers also note their findings don’t settle the open question as to whether prions or prion-like proteins naturally tackle bacterial infections in our body.

At the same time, they do argue their work provides a strong proof of concept that prionins identified through AI can be viable antibiotic candidates for further testing.

“For a long time, drug discovery has been limited not only by what we can test, but by where we choose to look,” said senior study author César de la Fuente, director of the Machine Biology Group at the University of Pennsylvania Perelman School of Medicine, in a statement from the university. “AI is changing that. It gives us a way to search the hidden layers of biology and ask whether molecules associated with one story—in this case, disease—may also carry another story with therapeutic potential.”

With any luck, the proteins known for causing the scariest diseases around could someday turn into our antibacterial allies.

#Deadly #Proteins #Mad #Cow #Disease #Fight #Superbugsantibiotic resistance,experimental drugs,prions">Deadly Proteins Behind Mad Cow Disease Might Help Us Fight SuperbugsDeadly Proteins Behind Mad Cow Disease Might Help Us Fight Superbugs
                The next frontier of antibiotics might come from an unexpected place. Recent research identifies potential antibiotic candidates from inside prions—proteins capable of causing some of the deadliest brain infections ever known, such as mad cow disease.

 Scientists at the University of Pennsylvania used artificial intelligence to rapidly search hundreds of prions and prion-like proteins for peptides with antibacterial activity. They found several dozen promising candidates, two of which have already shown results treating bacterial infections in mice. The team’s findings establish “prion-related proteins as a productive source space for antibiotic discovery,” the scientists wrote in their paper, published late last week in the journal Nature Microbiology.

 Good guy prions? Prions are some of the strangest things around. They’re the misfolded form of a protein naturally found in the body. When a prion comes across its “normal” counterpart, it can somehow induce the latter to turn into a prion itself, almost like a zombie infection.

 Classic prion disorders like mad cow disease and Creutzfeldt-Jakob disease are caused by the steady accumulation of one particular type of protein, aptly named the prion protein; these disorders are universally fatal. Some scientists have also argued that other neurodegenerative conditions, such as Alzheimer’s disease, are caused by other kinds of misfolded proteins that act in a similar way to prions.   According to the study researchers, there’s growing evidence that prions and prion-like proteins are more than just harbingers of death. Studies have found that the normal prion protein and the prion-like amyloid beta (one of the drivers of Alzheimer’s) can have antimicrobial activity, for instance. So the team decided to conduct a sweeping analysis looking for antimicrobial peptide fragments within these proteins.

 The researchers had previously built an AI model intended to predict the antimicrobial activity of any given peptide fragment, named APEX 1.1. Then they let APEX scan through 19.3 million short peptide fragments found in 2,897 prion and prion-like proteins. They initially uncovered 1,179 candidates, which the team narrowed down to 75 that showed the most potential. Of these, 59 were able to inhibit the growth of at least one bacterial germ in the lab, including 42 that did so at low levels (important for dosing considerations). Finally, the researchers tested two of the strongest candidates on the skin of mice infected with Acinetobacter baumannii, a common source of drug-resistant infections in people. The candidates appeared to be roughly as effective as polymyxin B, an existing antibiotic often used as a last resort drug for certain drug-resistant infections. The researchers have coined these antibacterial fragments collected from prions as “prionins.”

 The future of prionins More research is obviously needed to verify whether the team’s prionins can actually work as hoped—and safely—in people. The researchers also note their findings don’t settle the open question as to whether prions or prion-like proteins naturally tackle bacterial infections in our body. At the same time, they do argue their work provides a strong proof of concept that prionins identified through AI can be viable antibiotic candidates for further testing. “For a long time, drug discovery has been limited not only by what we can test, but by where we choose to look,” said senior study author César de la Fuente, director of the Machine Biology Group at the University of Pennsylvania Perelman School of Medicine, in a statement from the university. “AI is changing that. It gives us a way to search the hidden layers of biology and ask whether molecules associated with one story—in this case, disease—may also carry another story with therapeutic potential.”

 With any luck, the proteins known for causing the scariest diseases around could someday turn into our antibacterial allies.      #Deadly #Proteins #Mad #Cow #Disease #Fight #Superbugsantibiotic resistance,experimental drugs,prions

The next frontier of antibiotics might come from an unexpected place. Recent research identifies potential antibiotic candidates from inside prions—proteins capable of causing some of the deadliest brain infections ever known, such as mad cow disease.

Scientists at the University of Pennsylvania used artificial intelligence to rapidly search hundreds of prions and prion-like proteins for peptides with antibacterial activity. They found several dozen promising candidates, two of which have already shown results treating bacterial infections in mice.

The team’s findings establish “prion-related proteins as a productive source space for antibiotic discovery,” the scientists wrote in their paper, published late last week in the journal Nature Microbiology.

Good guy prions?

Prions are some of the strangest things around. They’re the misfolded form of a protein naturally found in the body. When a prion comes across its “normal” counterpart, it can somehow induce the latter to turn into a prion itself, almost like a zombie infection.

Classic prion disorders like mad cow disease and Creutzfeldt-Jakob disease are caused by the steady accumulation of one particular type of protein, aptly named the prion protein; these disorders are universally fatal. Some scientists have also argued that other neurodegenerative conditions, such as Alzheimer’s disease, are caused by other kinds of misfolded proteins that act in a similar way to prions.

According to the study researchers, there’s growing evidence that prions and prion-like proteins are more than just harbingers of death. Studies have found that the normal prion protein and the prion-like amyloid beta (one of the drivers of Alzheimer’s) can have antimicrobial activity, for instance. So the team decided to conduct a sweeping analysis looking for antimicrobial peptide fragments within these proteins.

The researchers had previously built an AI model intended to predict the antimicrobial activity of any given peptide fragment, named APEX 1.1. Then they let APEX scan through 19.3 million short peptide fragments found in 2,897 prion and prion-like proteins. They initially uncovered 1,179 candidates, which the team narrowed down to 75 that showed the most potential. Of these, 59 were able to inhibit the growth of at least one bacterial germ in the lab, including 42 that did so at low levels (important for dosing considerations).

Finally, the researchers tested two of the strongest candidates on the skin of mice infected with Acinetobacter baumannii, a common source of drug-resistant infections in people. The candidates appeared to be roughly as effective as polymyxin B, an existing antibiotic often used as a last resort drug for certain drug-resistant infections.

The researchers have coined these antibacterial fragments collected from prions as “prionins.”

The future of prionins

More research is obviously needed to verify whether the team’s prionins can actually work as hoped—and safely—in people. The researchers also note their findings don’t settle the open question as to whether prions or prion-like proteins naturally tackle bacterial infections in our body.

At the same time, they do argue their work provides a strong proof of concept that prionins identified through AI can be viable antibiotic candidates for further testing.

“For a long time, drug discovery has been limited not only by what we can test, but by where we choose to look,” said senior study author César de la Fuente, director of the Machine Biology Group at the University of Pennsylvania Perelman School of Medicine, in a statement from the university. “AI is changing that. It gives us a way to search the hidden layers of biology and ask whether molecules associated with one story—in this case, disease—may also carry another story with therapeutic potential.”

With any luck, the proteins known for causing the scariest diseases around could someday turn into our antibacterial allies.

#Deadly #Proteins #Mad #Cow #Disease #Fight #Superbugsantibiotic resistance,experimental drugs,prions

PS Svarva Floor Lamp

“Some stuff I did myself, like this one. The Svarva lamp we made with the design group Front for the PS 2009 collection. They were quite newly established and so we did an armchair and this lamp. The desire was to do a wooden turned lamp, but you should also be able to twist it, articulate it.”

“I felt that that would be very difficult to do. Along with a colleague in lighting at the time, I went to Hungary to this factory that was producing lamps for us. It was all metal tubes that they were doing, so we were a little bit hesitant whether they should be able to solve this. But they made some mock-ups based on the designer drawings. So we went there to have a look, and it was standing there. It was this floor lamp, and also a table lamp where the wooden beads were going in a circle and then up, like a snake.”

“What we didn’t know was that next to the lamp factory was this factory that was doing the turned wooden beads, the small individual pieces that we put together. None of us knew that. It was just pure serendipity. So they were turning these wooden beads, and the lamp factory was putting them on the metal tubes, just like on a necklace. They had very little to do, so they were happy to get the business.”

Image may contain Furniture Home Decor Rug Clothing Footwear Shoe and Chest Of Drawers

A Sinka Cabinet resides in Ejdemo’s hallway.

Courtesy of Johan Ejdemo

PS Sinka Cabinet

“I have another favorite from that PS 2009 collection, it’s in my hallway. The PS Sinka, with the small drawers with a wooden base. Sinka means “dovetail” in Swedish, so the name explaining that construction.”

“But the problem we had with this one was the packaging volume was too big. So what we did was each drawer is slightly shallower. So four drawers stack into each other. And four more drawers stack. There’s a little bit of a stopper in the back when you push them in, so they stop evenly at the front. There’s also a hidden compartment behind the smallest drawer. Really good drawers for all this stuff that is just lying around and getting in the way. In the top one I have all my keys that I no longer know where they go.”

PS Jonsberg Vases

“I have this vase from the PS collection to hold the cables [on my Samsung Serif TV]. It was a set, the Jonsberg vases by Hella Jongerius. There were four of them in different ceramic techniques. I had all four, but the terracotta one broke, which was a pity.” [It certainly is. These $39 vases now sell secondhand for $1,700 for a full set.]

“They’re inspired by different regions, and the different techniques are beautiful. I use the big black one for toilet paper in one bathroom. It’s not disrespect for the design. It’s just such a good design to stand there, and it makes the bathroom beautiful, and it can fit the toilet roll. So, why have something like an ugly stick? It’s nice for that.”

Pax Wardrobes

“Pax. We have to mention Pax. I have Pax wardrobes in a few rooms, but also I’m a little bit peculiar. Like in the kitchen, these veneer doors have been sanded and hand-painted by me, just to make them fit my house, in my space. I repaint them sometimes.”

Chipped Spraka pepper mills.

Chipped Spraka pepper mills.

Courtesy of Johan Ejdemo

Spraka Pepper Mills

“I have these pepper mills. One for white pepper, one for black pepper. That was also in a PS collection. We did these with Marcus Arvonen. These pepper mills are beautiful, and these have been around for, like, 20 years as well. They are pretty tall. A smaller version came later on, but I like these.”

“They have their chips, yes, but this just makes them nicer. It’s age. They’ve been around and are used every day. Everything has a little bit of imperfection. You can spend your whole life bothering about that, but there should be some imperfection in life. Fix it? Then something else needs fixing. It just moves. Leave it, be proud.”

Where’s the Billy Bookcase or Kallax?

“I don’t have a Billy in the house now. But there have been! Kallax? I have owned many. Brilliant piece. Really good for vinyl, because that’s the time they come from. I listen to a lot of vinyl.”

#Ikea #Products #Companys #Design #Chief #Personally #Ownsikea,design,home,furniture,household,interviews">These Are the 12 Ikea Products the Company’s Design Chief Personally OwnsThe Svarva lamp can be twisted into different shapes.
Courtesy of Johan EjdemoPS Svarva Floor Lamp“Some stuff I did myself, like this one. The Svarva lamp we made with the design group Front for the PS 2009 collection. They were quite newly established and so we did an armchair and this lamp. The desire was to do a wooden turned lamp, but you should also be able to twist it, articulate it.”“I felt that that would be very difficult to do. Along with a colleague in lighting at the time, I went to Hungary to this factory that was producing lamps for us. It was all metal tubes that they were doing, so we were a little bit hesitant whether they should be able to solve this. But they made some mock-ups based on the designer drawings. So we went there to have a look, and it was standing there. It was this floor lamp, and also a table lamp where the wooden beads were going in a circle and then up, like a snake.”“What we didn’t know was that next to the lamp factory was this factory that was doing the turned wooden beads, the small individual pieces that we put together. None of us knew that. It was just pure serendipity. So they were turning these wooden beads, and the lamp factory was putting them on the metal tubes, just like on a necklace. They had very little to do, so they were happy to get the business.”A Sinka Cabinet resides in Ejdemo’s hallway.
Courtesy of Johan EjdemoPS Sinka Cabinet“I have another favorite from that PS 2009 collection, it’s in my hallway. The PS Sinka, with the small drawers with a wooden base. Sinka means “dovetail” in Swedish, so the name explaining that construction.”“But the problem we had with this one was the packaging volume was too big. So what we did was each drawer is slightly shallower. So four drawers stack into each other. And four more drawers stack. There’s a little bit of a stopper in the back when you push them in, so they stop evenly at the front. There’s also a hidden compartment behind the smallest drawer. Really good drawers for all this stuff that is just lying around and getting in the way. In the top one I have all my keys that I no longer know where they go.”PS Jonsberg Vases“I have this vase from the PS collection to hold the cables [on my Samsung Serif TV]. It was a set, the Jonsberg vases by Hella Jongerius. There were four of them in different ceramic techniques. I had all four, but the terracotta one broke, which was a pity.” [It certainly is. These  vases now sell secondhand for ,700 for a full set.]“They’re inspired by different regions, and the different techniques are beautiful. I use the big black one for toilet paper in one bathroom. It’s not disrespect for the design. It’s just such a good design to stand there, and it makes the bathroom beautiful, and it can fit the toilet roll. So, why have something like an ugly stick? It’s nice for that.”Pax Wardrobes“Pax. We have to mention Pax. I have Pax wardrobes in a few rooms, but also I’m a little bit peculiar. Like in the kitchen, these veneer doors have been sanded and hand-painted by me, just to make them fit my house, in my space. I repaint them sometimes.”Chipped Spraka pepper mills.
Courtesy of Johan EjdemoSpraka Pepper Mills“I have these pepper mills. One for white pepper, one for black pepper. That was also in a PS collection. We did these with Marcus Arvonen. These pepper mills are beautiful, and these have been around for, like, 20 years as well. They are pretty tall. A smaller version came later on, but I like these.”“They have their chips, yes, but this just makes them nicer. It’s age. They’ve been around and are used every day. Everything has a little bit of imperfection. You can spend your whole life bothering about that, but there should be some imperfection in life. Fix it? Then something else needs fixing. It just moves. Leave it, be proud.”Where’s the Billy Bookcase or Kallax?“I don’t have a Billy in the house now. But there have been! Kallax? I have owned many. Brilliant piece. Really good for vinyl, because that’s the time they come from. I listen to a lot of vinyl.”#Ikea #Products #Companys #Design #Chief #Personally #Ownsikea,design,home,furniture,household,interviews

Svarva lamp we made with the design group Front for the PS 2009 collection. They were quite newly established and so we did an armchair and this lamp. The desire was to do a wooden turned lamp, but you should also be able to twist it, articulate it.”

“I felt that that would be very difficult to do. Along with a colleague in lighting at the time, I went to Hungary to this factory that was producing lamps for us. It was all metal tubes that they were doing, so we were a little bit hesitant whether they should be able to solve this. But they made some mock-ups based on the designer drawings. So we went there to have a look, and it was standing there. It was this floor lamp, and also a table lamp where the wooden beads were going in a circle and then up, like a snake.”

“What we didn’t know was that next to the lamp factory was this factory that was doing the turned wooden beads, the small individual pieces that we put together. None of us knew that. It was just pure serendipity. So they were turning these wooden beads, and the lamp factory was putting them on the metal tubes, just like on a necklace. They had very little to do, so they were happy to get the business.”

Image may contain Furniture Home Decor Rug Clothing Footwear Shoe and Chest Of Drawers

A Sinka Cabinet resides in Ejdemo’s hallway.

Courtesy of Johan Ejdemo

PS Sinka Cabinet

“I have another favorite from that PS 2009 collection, it’s in my hallway. The PS Sinka, with the small drawers with a wooden base. Sinka means “dovetail” in Swedish, so the name explaining that construction.”

“But the problem we had with this one was the packaging volume was too big. So what we did was each drawer is slightly shallower. So four drawers stack into each other. And four more drawers stack. There’s a little bit of a stopper in the back when you push them in, so they stop evenly at the front. There’s also a hidden compartment behind the smallest drawer. Really good drawers for all this stuff that is just lying around and getting in the way. In the top one I have all my keys that I no longer know where they go.”

PS Jonsberg Vases

“I have this vase from the PS collection to hold the cables [on my Samsung Serif TV]. It was a set, the Jonsberg vases by Hella Jongerius. There were four of them in different ceramic techniques. I had all four, but the terracotta one broke, which was a pity.” [It certainly is. These $39 vases now sell secondhand for $1,700 for a full set.]

“They’re inspired by different regions, and the different techniques are beautiful. I use the big black one for toilet paper in one bathroom. It’s not disrespect for the design. It’s just such a good design to stand there, and it makes the bathroom beautiful, and it can fit the toilet roll. So, why have something like an ugly stick? It’s nice for that.”

Pax Wardrobes

“Pax. We have to mention Pax. I have Pax wardrobes in a few rooms, but also I’m a little bit peculiar. Like in the kitchen, these veneer doors have been sanded and hand-painted by me, just to make them fit my house, in my space. I repaint them sometimes.”

Chipped Spraka pepper mills.

Chipped Spraka pepper mills.

Courtesy of Johan Ejdemo

Spraka Pepper Mills

“I have these pepper mills. One for white pepper, one for black pepper. That was also in a PS collection. We did these with Marcus Arvonen. These pepper mills are beautiful, and these have been around for, like, 20 years as well. They are pretty tall. A smaller version came later on, but I like these.”

“They have their chips, yes, but this just makes them nicer. It’s age. They’ve been around and are used every day. Everything has a little bit of imperfection. You can spend your whole life bothering about that, but there should be some imperfection in life. Fix it? Then something else needs fixing. It just moves. Leave it, be proud.”

Where’s the Billy Bookcase or Kallax?

“I don’t have a Billy in the house now. But there have been! Kallax? I have owned many. Brilliant piece. Really good for vinyl, because that’s the time they come from. I listen to a lot of vinyl.”

#Ikea #Products #Companys #Design #Chief #Personally #Ownsikea,design,home,furniture,household,interviews">These Are the 12 Ikea Products the Company’s Design Chief Personally Owns
Image may contain Lamp Chair Furniture Art Painting and Floor Lamp

The Svarva lamp can be twisted into different shapes.

Courtesy of Johan Ejdemo

PS Svarva Floor Lamp

“Some stuff I did myself, like this one. The Svarva lamp we made with the design group Front for the PS 2009 collection. They were quite newly established and so we did an armchair and this lamp. The desire was to do a wooden turned lamp, but you should also be able to twist it, articulate it.”

“I felt that that would be very difficult to do. Along with a colleague in lighting at the time, I went to Hungary to this factory that was producing lamps for us. It was all metal tubes that they were doing, so we were a little bit hesitant whether they should be able to solve this. But they made some mock-ups based on the designer drawings. So we went there to have a look, and it was standing there. It was this floor lamp, and also a table lamp where the wooden beads were going in a circle and then up, like a snake.”

“What we didn’t know was that next to the lamp factory was this factory that was doing the turned wooden beads, the small individual pieces that we put together. None of us knew that. It was just pure serendipity. So they were turning these wooden beads, and the lamp factory was putting them on the metal tubes, just like on a necklace. They had very little to do, so they were happy to get the business.”

Image may contain Furniture Home Decor Rug Clothing Footwear Shoe and Chest Of Drawers

A Sinka Cabinet resides in Ejdemo’s hallway.

Courtesy of Johan Ejdemo

PS Sinka Cabinet

“I have another favorite from that PS 2009 collection, it’s in my hallway. The PS Sinka, with the small drawers with a wooden base. Sinka means “dovetail” in Swedish, so the name explaining that construction.”

“But the problem we had with this one was the packaging volume was too big. So what we did was each drawer is slightly shallower. So four drawers stack into each other. And four more drawers stack. There’s a little bit of a stopper in the back when you push them in, so they stop evenly at the front. There’s also a hidden compartment behind the smallest drawer. Really good drawers for all this stuff that is just lying around and getting in the way. In the top one I have all my keys that I no longer know where they go.”

PS Jonsberg Vases

“I have this vase from the PS collection to hold the cables [on my Samsung Serif TV]. It was a set, the Jonsberg vases by Hella Jongerius. There were four of them in different ceramic techniques. I had all four, but the terracotta one broke, which was a pity.” [It certainly is. These $39 vases now sell secondhand for $1,700 for a full set.]

“They’re inspired by different regions, and the different techniques are beautiful. I use the big black one for toilet paper in one bathroom. It’s not disrespect for the design. It’s just such a good design to stand there, and it makes the bathroom beautiful, and it can fit the toilet roll. So, why have something like an ugly stick? It’s nice for that.”

Pax Wardrobes

“Pax. We have to mention Pax. I have Pax wardrobes in a few rooms, but also I’m a little bit peculiar. Like in the kitchen, these veneer doors have been sanded and hand-painted by me, just to make them fit my house, in my space. I repaint them sometimes.”

Chipped Spraka pepper mills.

Chipped Spraka pepper mills.

Courtesy of Johan Ejdemo

Spraka Pepper Mills

“I have these pepper mills. One for white pepper, one for black pepper. That was also in a PS collection. We did these with Marcus Arvonen. These pepper mills are beautiful, and these have been around for, like, 20 years as well. They are pretty tall. A smaller version came later on, but I like these.”

“They have their chips, yes, but this just makes them nicer. It’s age. They’ve been around and are used every day. Everything has a little bit of imperfection. You can spend your whole life bothering about that, but there should be some imperfection in life. Fix it? Then something else needs fixing. It just moves. Leave it, be proud.”

Where’s the Billy Bookcase or Kallax?

“I don’t have a Billy in the house now. But there have been! Kallax? I have owned many. Brilliant piece. Really good for vinyl, because that’s the time they come from. I listen to a lot of vinyl.”

#Ikea #Products #Companys #Design #Chief #Personally #Ownsikea,design,home,furniture,household,interviews

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