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A Gene Editing Therapy Cut Cholesterol Levels by Half

A Gene Editing Therapy Cut Cholesterol Levels by Half

In a step toward the wider use of gene editing, a treatment that uses Crispr successfully slashed high cholesterol levels in a small number of people.

In a trial conducted by Swiss biotech company Crispr Therapeutics, 15 participants received a one-time infusion meant to switch off a gene in the liver called ANGPTL3. Though rare, some people are born with a mutation in this gene that protects against heart disease with no apparent adverse consequences.

The highest dose tested in the trial reduced both “bad” LDL cholesterol and triglycerides by an average of 50 percent within two weeks after treatment. The effects lasted at least 60 days, the length of the trial. The results were presented today at the American Heart Association’s annual meeting and published in The New England Journal of Medicine.

The Nobel Prize–winning Crispr technology has mostly been used to address rare diseases, but these latest findings, while early, add to the evidence that the DNA-editing tool could be used to treat common conditions as well.

“This will probably be one of the biggest moments in the arc of Crispr’s development in medicine,” Samarth Kulkarni, CEO of Crispr Therapeutics, tells WIRED. The company is behind the only approved gene-editing treatment on the market, Casgevy, which treats sickle cell disease and beta thalassemia.

The American Heart Association estimates that about a quarter of adults in the US have elevated LDL levels. A similar number have high triglycerides. LDL cholesterol is the waxy substance in the blood that can clog and harden arteries over time. Triglycerides, meanwhile, are the most common type of fat found in the body. High levels of both raise the risk of heart attack and stroke.

The Phase I trial was conducted in the UK, Australia, and New Zealand between June 2024 and August 2025. Participants were between the ages of 31 and 68 and had uncontrolled levels of LDL cholesterol and triglycerides. The trial tested five different doses of the Crispr infusion, which took about two and a half hours on average to administer.

“These are very sick people,” says Steven Nissen, senior author and chief academic officer of the Heart, Vascular and Thoracic Institute at Cleveland Clinic, which independently confirmed the trial’s results. “The tragedy of this disease is not just that people die young, but some of them will have a heart attack, and their lives are never the same again. They don’t get back to work, they develop heart failure.”

One trial participant, a 51-year-old man, died six months after receiving the lowest dose of the treatment, which was not associated with a lowering of cholesterol and triglycerides. The death was related to his existing heart disease, not the experimental Crispr treatment. The man had a rare, inherited genetic form of high cholesterol and previously had several procedures to improve blood flow to his heart.

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#Gene #Editing #Therapy #Cut #Cholesterol #Levels

Today’s Wordle answer should be easy to solve if you love coziness.

If you just want to be told today’s word, you can jump to the bottom of this article for today’s Wordle solution revealed. But if you’d rather solve it yourself, keep reading for some clues, tips, and strategies to assist you.

Where did Wordle come from?

Originally created by engineer Josh Wardle as a gift for his partner, Wordle rapidly spread to become an international phenomenon, with thousands of people around the globe playing every day. Alternate Wordle versions created by fans also sprang up, including battle royale Squabble, music identification game Heardle, and variations like Dordle and Quordle that make you guess multiple words at once

Wordle eventually became so popular that it was purchased by the New York Times, and TikTok creators even livestream themselves playing.

What’s the best Wordle starting word?

The best Wordle starting word is the one that speaks to you. But if you prefer to be strategic in your approach, we have a few ideas to help you pick a word that might help you find the solution faster. One tip is to select a word that includes at least two different vowels, plus some common consonants like S, T, R, or N.

What happened to the Wordle archive?

The entire archive of past Wordle puzzles was originally available for anyone to enjoy whenever they felt like it, but it was later taken down, with the website’s creator stating it was done at the request of the New York Times. However, the New York Times then rolled out its own Wordle Archive, available only to NYT Games subscribers.

Is Wordle getting harder?

It might feel like Wordle is getting harder, but it actually isn’t any more difficult than when it first began. You can turn on Wordle‘s Hard Mode if you’re after more of a challenge, though.

Here’s a subtle hint for today’s Wordle answer:

A hooded jacket.

Mashable 101 Fan Fave: Vote for your favorite creators today

Does today’s Wordle answer have a double letter?

The letter A appears twice

Today’s Wordle is a 5-letter word that starts with…

Today’s Wordle starts with the letter P.

The Wordle answer today is…

Get your last guesses in now, because it’s your final chance to solve today’s Wordle before we reveal the solution.

Drumroll please!

The solution to today’s Wordle is…

PARKA

Don’t feel down if you didn’t manage to guess it this time. There will be a new Wordle for you to stretch your brain with tomorrow, and we’ll be back again to guide you with more helpful hints. Are you also playing NYT Strands? See hints and answers for today’s Strands.

Reporting by Chance Townsend, Caitlin Welsh, Sam Haysom, Amanda Yeo, Shannon Connellan, Cecily Mauran, Mike Pearl, and Adam Rosenberg contributed to this article.

If you’re looking for more puzzles, Mashable’s got games now! Check out our games hub for Mahjong, Sudoku, free crossword, and more.

Not the day you’re after? Here’s the solution to yesterday’s Wordle.

#Wordle #today #answer #hints">Wordle today: The answer and hints for May 10, 2026
                                            
                                                            Today’s Wordle answer should be easy to solve if you love coziness.If you just want to be told today’s word, you can jump to the bottom of this article for today’s Wordle solution revealed. But if you’d rather solve it yourself, keep reading for some clues, tips, and strategies to assist you.
        SEE ALSO:
        
            Mahjong, Sudoku, free crossword, and more: Play games on Mashable
            
        
    

        SEE ALSO:
        
            NYT Connections hints today: Clues, answers for May 10, 2026
            
        
    
Where did Wordle come from?Originally created by engineer Josh Wardle as a gift for his partner, Wordle rapidly spread to become an international phenomenon, with thousands of people around the globe playing every day. Alternate Wordle versions created by fans also sprang up, including battle royale Squabble, music identification game Heardle, and variations like Dordle and Quordle that make you guess multiple words at once. Wordle eventually became so popular that it was purchased by the New York Times, and TikTok creators even livestream themselves playing.What’s the best Wordle starting word?The best Wordle starting word is the one that speaks to you. But if you prefer to be strategic in your approach, we have a few ideas to help you pick a word that might help you find the solution faster. One tip is to select a word that includes at least two different vowels, plus some common consonants like S, T, R, or N.What happened to the Wordle archive?The entire archive of past Wordle puzzles was originally available for anyone to enjoy whenever they felt like it, but it was later taken down, with the website’s creator stating it was done at the request of the New York Times. However, the New York Times then rolled out its own Wordle Archive, available only to NYT Games subscribers. Is Wordle getting harder?It might feel like Wordle is getting harder, but it actually isn’t any more difficult than when it first began. You can turn on Wordle‘s Hard Mode if you’re after more of a challenge, though.
        SEE ALSO:
        
            NYT Pips hints, answers for May 10, 2026
            
        
    
Here’s a subtle hint for today’s Wordle answer:A hooded jacket.
        
            Mashable Top Stories
        
        
    
Mashable 101 Fan Fave: Vote for your favorite creators todayDoes today’s Wordle answer have a double letter?The letter A appears twiceToday’s Wordle is a 5-letter word that starts with…Today’s Wordle starts with the letter P.
        SEE ALSO:
        
            Wordle-obsessed? These are the best word games to play IRL.
            
        
    
The Wordle answer today is…Get your last guesses in now, because it’s your final chance to solve today’s Wordle before we reveal the solution.Drumroll please!The solution to today’s Wordle is…PARKADon’t feel down if you didn’t manage to guess it this time. There will be a new Wordle for you to stretch your brain with tomorrow, and we’ll be back again to guide you with more helpful hints. Are you also playing NYT Strands? See hints and answers for today’s Strands.Reporting by Chance Townsend, Caitlin Welsh, Sam Haysom, Amanda Yeo, Shannon Connellan, Cecily Mauran, Mike Pearl, and Adam Rosenberg contributed to this article.If you’re looking for more puzzles, Mashable’s got games now! Check out our games hub for Mahjong, Sudoku, free crossword, and more.Not the day you’re after? Here’s the solution to yesterday’s Wordle.

                    
                                            
                            
                        
                                    #Wordle #today #answer #hints

Wordle answer should be easy to solve if you love coziness.

If you just want to be told today’s word, you can jump to the bottom of this article for today’s Wordle solution revealed. But if you’d rather solve it yourself, keep reading for some clues, tips, and strategies to assist you.

Where did Wordle come from?

Originally created by engineer Josh Wardle as a gift for his partner, Wordle rapidly spread to become an international phenomenon, with thousands of people around the globe playing every day. Alternate Wordle versions created by fans also sprang up, including battle royale Squabble, music identification game Heardle, and variations like Dordle and Quordle that make you guess multiple words at once

Wordle eventually became so popular that it was purchased by the New York Times, and TikTok creators even livestream themselves playing.

What’s the best Wordle starting word?

The best Wordle starting word is the one that speaks to you. But if you prefer to be strategic in your approach, we have a few ideas to help you pick a word that might help you find the solution faster. One tip is to select a word that includes at least two different vowels, plus some common consonants like S, T, R, or N.

What happened to the Wordle archive?

The entire archive of past Wordle puzzles was originally available for anyone to enjoy whenever they felt like it, but it was later taken down, with the website’s creator stating it was done at the request of the New York Times. However, the New York Times then rolled out its own Wordle Archive, available only to NYT Games subscribers.

Is Wordle getting harder?

It might feel like Wordle is getting harder, but it actually isn’t any more difficult than when it first began. You can turn on Wordle‘s Hard Mode if you’re after more of a challenge, though.

Here’s a subtle hint for today’s Wordle answer:

A hooded jacket.

Mashable 101 Fan Fave: Vote for your favorite creators today

Does today’s Wordle answer have a double letter?

The letter A appears twice

Today’s Wordle is a 5-letter word that starts with…

Today’s Wordle starts with the letter P.

The Wordle answer today is…

Get your last guesses in now, because it’s your final chance to solve today’s Wordle before we reveal the solution.

Drumroll please!

The solution to today’s Wordle is…

PARKA

Don’t feel down if you didn’t manage to guess it this time. There will be a new Wordle for you to stretch your brain with tomorrow, and we’ll be back again to guide you with more helpful hints. Are you also playing NYT Strands? See hints and answers for today’s Strands.

Reporting by Chance Townsend, Caitlin Welsh, Sam Haysom, Amanda Yeo, Shannon Connellan, Cecily Mauran, Mike Pearl, and Adam Rosenberg contributed to this article.

If you’re looking for more puzzles, Mashable’s got games now! Check out our games hub for Mahjong, Sudoku, free crossword, and more.

Not the day you’re after? Here’s the solution to yesterday’s Wordle.

#Wordle #today #answer #hints">Wordle today: The answer and hints for May 10, 2026

Today’s Wordle answer should be easy to solve if you love coziness.

If you just want to be told today’s word, you can jump to the bottom of this article for today’s Wordle solution revealed. But if you’d rather solve it yourself, keep reading for some clues, tips, and strategies to assist you.

Where did Wordle come from?

Originally created by engineer Josh Wardle as a gift for his partner, Wordle rapidly spread to become an international phenomenon, with thousands of people around the globe playing every day. Alternate Wordle versions created by fans also sprang up, including battle royale Squabble, music identification game Heardle, and variations like Dordle and Quordle that make you guess multiple words at once

Wordle eventually became so popular that it was purchased by the New York Times, and TikTok creators even livestream themselves playing.

What’s the best Wordle starting word?

The best Wordle starting word is the one that speaks to you. But if you prefer to be strategic in your approach, we have a few ideas to help you pick a word that might help you find the solution faster. One tip is to select a word that includes at least two different vowels, plus some common consonants like S, T, R, or N.

What happened to the Wordle archive?

The entire archive of past Wordle puzzles was originally available for anyone to enjoy whenever they felt like it, but it was later taken down, with the website’s creator stating it was done at the request of the New York Times. However, the New York Times then rolled out its own Wordle Archive, available only to NYT Games subscribers.

Is Wordle getting harder?

It might feel like Wordle is getting harder, but it actually isn’t any more difficult than when it first began. You can turn on Wordle‘s Hard Mode if you’re after more of a challenge, though.

Here’s a subtle hint for today’s Wordle answer:

A hooded jacket.

Mashable 101 Fan Fave: Vote for your favorite creators today

Does today’s Wordle answer have a double letter?

The letter A appears twice

Today’s Wordle is a 5-letter word that starts with…

Today’s Wordle starts with the letter P.

The Wordle answer today is…

Get your last guesses in now, because it’s your final chance to solve today’s Wordle before we reveal the solution.

Drumroll please!

The solution to today’s Wordle is…

PARKA

Don’t feel down if you didn’t manage to guess it this time. There will be a new Wordle for you to stretch your brain with tomorrow, and we’ll be back again to guide you with more helpful hints. Are you also playing NYT Strands? See hints and answers for today’s Strands.

Reporting by Chance Townsend, Caitlin Welsh, Sam Haysom, Amanda Yeo, Shannon Connellan, Cecily Mauran, Mike Pearl, and Adam Rosenberg contributed to this article.

If you’re looking for more puzzles, Mashable’s got games now! Check out our games hub for Mahjong, Sudoku, free crossword, and more.

Not the day you’re after? Here’s the solution to yesterday’s Wordle.

#Wordle #today #answer #hints

The last-gen 360 Vis Nav offers a whopping 65 air watts of suction, allowing it to pull dirt, dust, and pet hair from carpets impressively well. In her brief time testing the robovac, my colleague Jennifer Pattison Tuohy said the Dyson “demolished a pile of dry oatmeal in seconds,” adding that she briefly worried it might even suck up the tassels on her large rug (it didn’t). By comparison, many robot vacuums — including Dyson’s new $1,200 Spot + Scrub AI — require multiple passes to fully eradicate the same kind of mess on your floor.

What’s more, the robovac’s small, D-shaped design and the location of its ultra-fluffy brush allow it to dig into edges and corners more effectively than many of the more roundish robot vacuums, while its lower profile lets it easily get under most beds and sofas. The roomy 500ml dustbin also means you likely won’t need to empty it too often, while Dyson’s built-in handle and terrific quick-release button make removing said bin a relatively simple task when it’s time to do so.

While it is undeniably powerful, it’s worth noting that the 360 Vis Nav lacks a few features found on some of its more modern rivals. Although its navigation worked well enough during our testing, it lacks AI-powered obstacle avoidance and doesn’t come with a self-emptying dock. Battery life is also relatively short at around 65 minutes per charge. Nonetheless, if your top priority is quickly removing dust, dirt, and pet hair from carpets without multiple passes, the Dyson remains an option worth considering, especially at this discounted price.

#Dysons #powerful #Vis #Nav #robovac #limited #timeDeals,Gadgets,Smart Home,Tech,Verge Shopping">Dyson’s powerful 360 Vis Nav robovac is down to 9.99 for a limited timeIf you’re tired of running your vacuum multiple times just to get the dirt and debris out of the carpets in your living room, Dyson’s 360 Vis Nav is worth a look. It’s one of the more powerful robot vacuums currently available, and now through May 11th (or while supplies last), it’s on sale at Woot for an all-time low of 9.99 (9 off) with a full two-year warranty.The last-gen 360 Vis Nav offers a whopping 65 air watts of suction, allowing it to pull dirt, dust, and pet hair from carpets impressively well. In her brief time testing the robovac, my colleague Jennifer Pattison Tuohy said the Dyson “demolished a pile of dry oatmeal in seconds,” adding that she briefly worried it might even suck up the tassels on her large rug (it didn’t). By comparison, many robot vacuums — including Dyson’s new ,200 Spot + Scrub AI — require multiple passes to fully eradicate the same kind of mess on your floor.What’s more, the robovac’s small, D-shaped design and the location of its ultra-fluffy brush allow it to dig into edges and corners more effectively than many of the more roundish robot vacuums, while its lower profile lets it easily get under most beds and sofas. The roomy 500ml dustbin also means you likely won’t need to empty it too often, while Dyson’s built-in handle and terrific quick-release button make removing said bin a relatively simple task when it’s time to do so.While it is undeniably powerful, it’s worth noting that the 360 Vis Nav lacks a few features found on some of its more modern rivals. Although its navigation worked well enough during our testing, it lacks AI-powered obstacle avoidance and doesn’t come with a self-emptying dock. Battery life is also relatively short at around 65 minutes per charge. Nonetheless, if your top priority is quickly removing dust, dirt, and pet hair from carpets without multiple passes, the Dyson remains an option worth considering, especially at this discounted price.#Dysons #powerful #Vis #Nav #robovac #limited #timeDeals,Gadgets,Smart Home,Tech,Verge Shopping

Woot for an all-time low of $279.99 ($919 off) with a full two-year warranty.

The last-gen 360 Vis Nav offers a whopping 65 air watts of suction, allowing it to pull dirt, dust, and pet hair from carpets impressively well. In her brief time testing the robovac, my colleague Jennifer Pattison Tuohy said the Dyson “demolished a pile of dry oatmeal in seconds,” adding that she briefly worried it might even suck up the tassels on her large rug (it didn’t). By comparison, many robot vacuums — including Dyson’s new $1,200 Spot + Scrub AI — require multiple passes to fully eradicate the same kind of mess on your floor.

What’s more, the robovac’s small, D-shaped design and the location of its ultra-fluffy brush allow it to dig into edges and corners more effectively than many of the more roundish robot vacuums, while its lower profile lets it easily get under most beds and sofas. The roomy 500ml dustbin also means you likely won’t need to empty it too often, while Dyson’s built-in handle and terrific quick-release button make removing said bin a relatively simple task when it’s time to do so.

While it is undeniably powerful, it’s worth noting that the 360 Vis Nav lacks a few features found on some of its more modern rivals. Although its navigation worked well enough during our testing, it lacks AI-powered obstacle avoidance and doesn’t come with a self-emptying dock. Battery life is also relatively short at around 65 minutes per charge. Nonetheless, if your top priority is quickly removing dust, dirt, and pet hair from carpets without multiple passes, the Dyson remains an option worth considering, especially at this discounted price.

#Dysons #powerful #Vis #Nav #robovac #limited #timeDeals,Gadgets,Smart Home,Tech,Verge Shopping">Dyson’s powerful 360 Vis Nav robovac is down to $279.99 for a limited time

If you’re tired of running your vacuum multiple times just to get the dirt and debris out of the carpets in your living room, Dyson’s 360 Vis Nav is worth a look. It’s one of the more powerful robot vacuums currently available, and now through May 11th (or while supplies last), it’s on sale at Woot for an all-time low of $279.99 ($919 off) with a full two-year warranty.

The last-gen 360 Vis Nav offers a whopping 65 air watts of suction, allowing it to pull dirt, dust, and pet hair from carpets impressively well. In her brief time testing the robovac, my colleague Jennifer Pattison Tuohy said the Dyson “demolished a pile of dry oatmeal in seconds,” adding that she briefly worried it might even suck up the tassels on her large rug (it didn’t). By comparison, many robot vacuums — including Dyson’s new $1,200 Spot + Scrub AI — require multiple passes to fully eradicate the same kind of mess on your floor.

What’s more, the robovac’s small, D-shaped design and the location of its ultra-fluffy brush allow it to dig into edges and corners more effectively than many of the more roundish robot vacuums, while its lower profile lets it easily get under most beds and sofas. The roomy 500ml dustbin also means you likely won’t need to empty it too often, while Dyson’s built-in handle and terrific quick-release button make removing said bin a relatively simple task when it’s time to do so.

While it is undeniably powerful, it’s worth noting that the 360 Vis Nav lacks a few features found on some of its more modern rivals. Although its navigation worked well enough during our testing, it lacks AI-powered obstacle avoidance and doesn’t come with a self-emptying dock. Battery life is also relatively short at around 65 minutes per charge. Nonetheless, if your top priority is quickly removing dust, dirt, and pet hair from carpets without multiple passes, the Dyson remains an option worth considering, especially at this discounted price.

#Dysons #powerful #Vis #Nav #robovac #limited #timeDeals,Gadgets,Smart Home,Tech,Verge Shopping

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