Israel carried out a strike against Hamas’ senior leadership on Tuesday in Doha, the capital of Qatar, marking a significant escalation in Israel’s multifront conflict in the region.

Loud explosions were heard in Doha, and according to video verified by NBC News, smoke was seen over an area that is both residential and home to a number of foreign embassies.

The Israel Defense Forces and Shin Bet intelligence agency said in a statement on X that they had carried out “a precise strike targeting the senior leadership of the Hamas terrorist organization.”

While Israel did not say it had struck Qatar, where Hamas stations its headquarters outside of Gaza, an Israeli and a U.S. official told NBC News that the militant group’s offices had been targeted in Doha.

Israeli Prime Minister Benjamin Netanyahu, in a statement on X, called it a “wholly independent Israeli operation” that targeted Hamas’ “top terrorist chieftains.”

“Israel takes full responsibility,” he said, while not confirming that the strike had been on Doha.

The attack followed President Donald Trump’s warning to Hamas to agree a proposed ceasefire deal that had been accepted by Israel.

“This is my last warning, there will not be another one!” Trump wrote on Truth social on Sunday.

A joint statement from office and Defense Minister Israel Katz described the attack on Hamas as a retaliation for “murderous attacks in Jerusalem and Gaza.” On Monday, two gunmen opened fire at a Jerusalem bus stop killing six people.

Hamas took responsibility for the shootings shortly before the strike on Doha.

The Qatari government condemned what it called a “cowardly Israeli attack” targeting Hamas’ headquarters.

“This criminal assault constitutes a blatant violation of all international laws and norms, and poses a serious threat to the security and safety of Qataris and residents in Qatar,” the government said in a statement.

It said “it will not tolerate this reckless and irresponsible Israeli behavior, which continuously undermines the region’s security, or any action targeting its security and sovereignty.”

The bombing was also condemned by the United Arab Emirates, which had seen a significant warming of ties with Israel in the last few years with the President Donald Trump-mediated Abraham Accords.

The UAE’s Foreign Ministry described the bombing of Hamas’ so-called bureau of political affairs as “a dangerous assault on international law” and an “irresponsible escalation.”

Saudi Arabia, a regional power that Israel has sought to establish official relations with, also condemned the attack as “brutal.”

The U.S. Embassy issued a shelter-in-place order for their facilities after “reports of missile strikes occurring in Doha.”

Israeli government officials notified the U.S. that they were about to conduct a strike against senior Hamas leadership in advance of the strike in Doha, according to two U.S. officials briefed on the matter and a senior White House official. The officials said the U.S. did not have a lot of advance notice and made clear that the U.S. was not directly involved in the action.

Qatar has been home to much of the on-and-off negotiations since Oct. 7, 2023, and has been home to the Hamas officials who have been involved in the talks.

This is the second time this year Qatar was hit with a strike as it plays the intermediary in the region’s larger geopolitical conflict. Iran hit a U.S. military base in Qatar in June after Israel conducted strikes against Iran’s nuclear sites.