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65+ best Black Friday deals 2025: Apple, Kindle, Ninja on sale

65+ best Black Friday deals 2025: Apple, Kindle, Ninja on sale

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We’re officially back in Black Friday season, folks.

Though Black Friday falls on Nov. 28 this year, retailers are already kicking off sales. Best Buy dropped early deals and doorbusters on Oct. 31, and Target started its first holiday savings event on Nov. 6. Amazon kicked off its programming on Nov. 20, and Walmart hosted an early sale, but will get back in on the action on Nov. 25. We’ve spotted plenty of Black Friday-worthy deals that you can shop early to get ahead of your holiday list.

Keep checking back for the best Black Friday deals from Amazon, Target, Walmart, Best Buy, and beyond.

Best early Black Friday Apple deal

$749
at Amazon

$999
Save $250

 

Why we like it

The 13-inch MacBook Air is down to a record-low price of $749 ahead of Black Friday. This is our favorite laptop for students, thanks to its M4 silicon and slim design. This markdown is so good that even if it does happen to drop lower for Black Friday or Cyber Monday (and we’re not counting on it), you still score a great deal without all the chaos of Black Friday shopping.

More Apple deals

$699
at Best Buy

$799
Save $100

 

$949
at Amazon

$1,199
Save $250

 

Apple AirPods Pro 3 Noise Cancelling Heart Rate Wireless Earbuds

$219.99
at Amazon

$249
Save $29.01

Lowest price ever 🔥

$139
at Walmart

$239
Save $100

Lowest price ever 🔥

$429.99
at Best Buy

$549
Save $119.01

 

airtag on white background

$17.97
at Amazon

$29
Save $11.03

 

four apple airtags

$64.98
at Amazon

$99
Save $34.02

 

$349.99
at Amazon

$399
Save $49.01

 

$249
at Walmart

$499
Save $250

Lowest price ever 🔥

Best early Black Friday headphones deal

lunar blue bose quietcomfort ultra headphones

$299
at Best Buy

$429
Save $130

Lowest price ever 🔥

Why we like it

Read our full review of the Bose QuietComfort Ultra (Gen 1) headphones.

The Bose QC Ultra headphones have long been some of our favorite noise-cancelling headphones. Even though Bose recently replaced them with a new Gen 2 model, the originals are still an excellent value for your money — especially at the record low price of $299.

More Black Friday headphones and earbuds deals

$78
at Amazon

$129.99
Save $51.99

 

$199
at Bose

$299
Save $100

 

$249
at Amazon

$299
Save $50

Lowest price ever 🔥

$149
at Amazon

$199
Save $50

 

$54.95
at Walmart

$109.95
Save $55

 

Sony WH-1000XM5 Noise-Cancelling Headphones

$248
at Amazon

$399.99
Save $151.99

Lowest price ever 🔥

$107.99
at Amazon

$179.99
Save $72.00

 

Best early Black Friday robot vacuum deal

NARWAL Freo Z10 Ultra Robot Vacuum and Mop Combo, Dual RGB Cameras and Chips, AI Avoidance, 8N Corner to Edge Deep Cleaning, Dry-Wet Separation, 18000Pa, Hot Water Wash & Self-Emptying, Gray

$799.99
at Amazon

$1,299.99
Save $500

 

Why we like it

Senior Shopping Reporter Leah Stodart sees Narwal’s newest robot vacuum mop combo as a dupe for the $1,599.99 Roborock Saros 10R, our favorite robot vacuum of the year. Its edge cleaning is comparable thanks to dual spinning mopping pads that flex out from under the vacuum to scrub in corners and along walls. When mopping, the Freo Z10 Ultra ensures that it does a thorough job by taking a before-and-after picture of the spill, going back for another pass if necessary. The livestream pet camera is a bonus for homes with pets.

More robot vacuum and vacuum deals

$349.99
at Amazon

$449.99
Save $100

Editor’s pick ✅

$199
at Amazon

$219
Save $20

 

$399.99
at Walmart

$729.99
Save $330

Editor’s pick ✅

Dyson Big Ball Turbinehead Canister Vacuum

$229.99
at Walmart

$349.99
Save $120

 

Best early Black Friday TV deal

$547.99
at Walmart

$847.99
Save $300

Lowest price ever 🔥

Why we like it

“If you’re not sure what size TV to get, we consider 65 inches to be the sweet spot for most folks. While the Hisense U6 Mini LED QLED TV falls into the budget-friendly category, its specs don’t scream ‘budget’ at all. It features a Mini LED backlight system, which means its uses smaller LEDs to deliver a brighter and more detailed picture. Plus, it packs a 144Hz native refresh rate, WiFi 6 connectivity, support for HDR in Dolby Vision, the Fire TV OS, and on-board Alexa. Our friends at PCMag (also owned by Ziff Davis) called it ‘easily the brightest and most colorful budget-friendly TV we’ve tested.'” — Christina Buff, Mashable Contributor

More TV and streaming deals

$279.99
at Target

$449.99
Save $170

 

$798.99
at Amazon

$1,199.99
Save $401

 

$547.99
at Amazon

$847.99
Save $300

Lowest price ever 🔥

Samsung 55-Inch The Frame LS03F 4K QLED Smart TV (2025)

$897.99
at Amazon

$1,197.99
Save $300

Editor’s pick ✅

$199.99
at Best Buy

$329.99
Save $130

 

$448
at Walmart

$599.99
Save $151.99

 

$21.99
at Amazon

$39.99
Save $18.00

Lowest price ever 🔥

$29
at Amazon

$39.99
Save $10.99

 

Best Black Friday fitness tracker deal

$349
at Amazon

$499
Save $150

 

Why we like it

One of our favorite health trackers, the Oura Ring, just got a major markdown ahead of Black Friday. Right now, score the Oura Ring 4 for 30% off. It’s down to $349, saving you $150 off its $499 price tag. The Oura Ring 4 is our favorite smart ring at Mashable, providing holistic insights to help you manage stress and heart health.

More Black Friday fitness tracker deals

$299.99
at Amazon

$499.99
Save $200

 

$119.95
at Amazon

$199.95
Save $80.00

 

$199
at Amazon

$239
Save $40

 

$299
at Amazon

$359
Save $60

 

Best Black Friday kitchen deal

Ninja SLUSHi Professional Frozen Drink Maker with RapidChill Technology, 88 oz. Frozen Drink & Slushie Machine, 5 Preset Programs, Frozen Margaritas, Frappés, and More, Margarita, FS301TG

$269.99
at Amazon

$369.99
Save $100

 

Why we like it

The Ninja Slushi is a blast in any season — frozen margs in any flavor you want when it’s hot, apple cider slush or gingerbread frappé when it’s chilly. (Mashable Senior Shopping Reporter Leah Stodart loves her Slushi, and so do all of her friends.) A year after the first Slushi came out, Ninja released two larger capacity versions in a few fun colors. The 88-ounce model on sale for $269.99 at Amazon can make a slightly bigger batch than the original 72-ounce model, which is on sale for $249.99 at Walmart. $20 more for extra beverages and a chic green build? Sold. (If you want the purple one, it’s $269.99 at Target.)

More Black Friday kitchen deals

Nespresso Festive Vertuo Pop+ Deluxe Coffee and Espresso Maker by Breville with Milk Frother, Matte Black Gold

$129
at Amazon

$209.95
Save $80.95

 

$275
at Our Place

$325
Save $50

 

$634.99
at Amazon

$749.99
Save $115

 

$489.99
at Amazon

$699.99
Save $210

 

$139.99
at Target

$209.99
Save $70

 

$47.49
at Amazon

$71.99
Save $24.50

 

$179.99
at Amazon

$199.99
Save $20

 

$349.95
at Amazon

$499.99
Save $150.04

 

Best early Black Friday home deal

Score 25% off on Brooklinen bedding and bath linens.

Why we like it

The best early Black Friday deal for the home is at Brooklinen. Right now, the brand is offering 25% off across its products. You can find Brooklinen’s super-plush Turkish cotton bath towel bundle for just $107, saving you 30% off. All prices are marked, no discount code needed.

More early Black Friday home deals

$149.99
at Amazon

$199.99
Save $50

 

$139
at Amazon

$179.99
Save $40.99

 

$60
at Amazon

$75
Save $15

 

$144.90
at Amazon

$179
Save $34.10

 

$84.99
at Amazon

$108
Save $23.01

 

$449.99
at Target

$549.99
Save $100

 

Best early Black Friday power station deal

$349
at Amazon

$799
Save $450

Lowest price ever 🔥

Why we like it

Some of the year’s best Black Friday deals are in the power station category, where you’ll find discounts of 56% or more. And for so many reasons, this Anker Solix power station is our top pick for holiday shoppers. In our review, Mashable contributor Lauren Allain wrote that the “Anker Solix C1000 portable power station nails performance, design, and versatility,” awarding it a Mashable Choice Award. And now that it’s at a record-low price at Amazon, it’s neve been easier to recommend.

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More Black Friday power station deals

EF ECOFLOW Portable Power Station RIVER 2 Max 500, 499Wh LiFePO4 Battery/ 1 Hour Fast Charging, Up To 1000W Output Solar Generator (Solar Panel Optional) for Outdoor Camping/RVs/Home Use

$269
at Amazon

$449
Save $180

 

BLUETTI Elite 200 V2 Solar Generator with 2 200W Solar Panels Included (Ships Separately), 2073.6Wh Portable Power Station w/ 4 2600W AC Outlets, 17-Year Lifespan, LFP Power for Camping, Off-grid

$1,099
at Amazon

$2,299
Save $1,200

 

Jackery Explorer 2000 v2 Portable Power Station, 2042Wh LiFePO4 Home Backup Battery, 2200W Solar Generator with 20ms UPS, USB-C PD 100W Fast Charging for Emergencies, Power Outages, Outdoor Camping

$699
at Amazon

$1,499
Save $800

https://zdcs.link/z6DZMk

$348
at Amazon

$448.98
Save $100.98

 

Best early Black Friday outdoor deal

$78.99
at Amazon

$117.99
Save $39

 

Why we like it

Whether you’re shopping for outdoor deals to replenish your own gear or get a gift for the outdoorsman in your life, the best deal we’ve spotted is on the Coleman Sundome tent. This four-person tent is weatherproof, designed to block out wind and rain, and keep you dry. It’s down to $78.99 ahead of Black Friday, saving you $39 for 33% off its list price of $117.99.

More early Black Friday outdoor deals

$212.47
at Amazon

$271.49
Save $59.02

 

$280
at Amazon

$350
Save $70

 

$21.07
at Amazon

$46.99
Save $25.92

 

$9.99
at Amazon

$14.95
Save $4.96

 

$199.95
at Amazon

$249.99
Save $50.04

 

Score up to 40% off during REI’s Black Friday sale. Shop sleeping bags, outdoor blankets, camping furniture, and more.

More Black Friday deals from Amazon

Even though Amazon’s Black Friday sale hasn’t officially started (you have to wait until Nov. 20 for that), Amazon devices such as Fire TVs are already marked down in advance of the sale. In addition, you can find plenty of limited-time deals on popular gadgets, power stations, smart home tech, outdoor gear, and Christmas gifts. Amazon is also a great place to stock up on stocking stuffers, as you’ll find an abundance of deals under $25.

$84.98
at Amazon

$94.99
Save $10.01

 

Amazon Fire HD 10 tablet

$94.99
at Amazon

$194.99
Save $100.00

Lowest price ever 🔥

$349.99
at Amazon

$499.99
Save $150

 

$17.99
at Amazon

$29.99
Save $12

Editor’s pick ✅

Credit: National Tree Company

$199.98
at Amazon

$254.03
Save $54.05

Bonus coupon: Get Echo Pop & Amazon Smart Plug for $15

$99
at Amazon

$189.99
Save $90.99

 

$299.95
at Amazon

$549.99
Save $250.04

 

$119.99
at Amazon

$299.99
Save $180

 

$106.99
at Amazon

$143.99
Save $37.00

Refurbished with great reviews

Amazon Echo Dot (5th Gen, 2022 Release)

$31.99
at Amazon

$49.99
Save $18.00

 

$369.99
at Amazon

$479.99
Save $110

 

$79
at Amazon

$99
Save $20

Lowest price ever 🔥

$249.99
at Amazon

$299.99
Save $50

 

Nintendo Switch 2 Mario Kart World Bundle

$499
at Walmart

$1,049.66
Save $550.66

Editor’s pick ✅

More Black Friday deals from Walmart

As in years past, Walmart+ members get early access to the best Black Friday deals, and you can either sign up for a free trial or get 50% off a membership. Until its next official Black Friday sales event (mark your calendars for Nov. 25), the original Everything Store has great early deals on video games, kitchen gadgets, Legos, and even Dyson vacuums.

$34
at Walmart

$40.53
Save $6.53

 

$119
at Walmart

$329
Save $210

 

$1,128
at Walmart

$1,249.99
Save $121.99

 

$45
at Walmart

$62.97
Save $17.97

 

$78.99
at Walmart

$99.99
Save $21

 

$54.97
at Walmart

$69.99
Save $15.02

 

More Black Friday deals from Best Buy

Best Buy has an interesting Black Friday system: It’s been dropping new doorbusters every single Thursday since Halloween. Some of those deals have stuck around, and some are fleeting. You can plan ahead for the official Black Friday sale (kicking off on Nov. 20) with the Best Buy Black Friday ad scan, but here are some deals that are confirmed to be at their Black Friday prices.

$1,399.99
at Best Buy

$2,699.99
Save $1,300.00

 

$279.99
at Best Buy

$529.99
Save $250

 

$249
at Best Buy

$299
Save $50

 

$379.99
at Best Buy

$499.99
Save $120

 

$369.99
at Best Buy

$479.99
Save $110

 

$64.99

$129.99
Save $65.00

 

$199.99
at Best Buy

$349.99
Save $150

 

More Black Friday deals from Target

We’re scanning Target’s weekly ad to find the best early Black Friday deals of 2025, including plenty of products that are cheaper at Target than on Amazon. Strangely, that includes some of Amazon’s own products. So, if you’re a Target Circle member and you need a new kids’ tablet or espresso machine, now’s your chance to save.

$44.99
at Target

$99.99
Save $55.00

Costs $5 more at Amazon

$499.99
at Target

$779.95
Save $279.96

Costs $50 more at Amazon

Credit: Hearth & Hand with Magnolia

$149.99
at Target

$179.99
Save $30

 

Credit: Universal Music Group

$29.99
at Target

$34.99
Save $5.00

 

Live

Latest Updates




12 minutes ago | November 20, 2025

Not sure if you should check out as soon as you see a good deal, or wait in case you find something better? Check out our expert’s advice on rushing vs. waiting on Black Friday purchases.

58 minutes ago | November 20, 2025

With Amazon’s Black Friday sale comes a host of new earbuds deals. Shop the best selected by our audio expert.

1 hour ago | November 20, 2025

2 hours ago | November 20, 2025

Target announced that its Black Friday sale starts Sunday, Nov. 23, and runs through Saturday, Nov. 29. Stores will be closed on Thanksgiving Day. More deals will drop from Nov. 27 to Nov. 29.

4 hours ago | November 20, 2025

5 hours ago | November 20, 2025

5 hours ago | November 20, 2025

We predict that power stations will make a big impression over Black Friday. We’re expecting huge price drops on top brands like Bluetti, Jackery, DJI, and of course, Anker. The second-generation Anker Solix C1000 power station is down to under $350 at Amazon, and we’ve named it the best Black Friday deal on power stations so far.

7 hours ago | November 20, 2025

Apple deals always make a big impression over Black Friday, but a record-low price on the brand-new AirPods? That’s an absolute steal that we can’t ignore. Amazon launched its Black Friday sale on Nov. 20 and dropped prices on these new Apple earbuds. It’s not a huge discount, but it’s the lowest price for these buds yet.

8 hours ago | November 20, 2025

The DJI Mic Mini is one of those products that we keep a particularly close eye on. Mashable readers seems to absolutely love it and it goes on sale a lot. That’s a recipe for success, so we make sure we’re the first to tell you about any new price drops. And we have some good news: The DJI Mic Mini (2 TX, 1 RX, and Charging Case) is on sale for $78.90 in the Amazon Black Friday sale. That’s over $90 off and the lowest price we’ve ever seen.

$78.90
at Amazon

$169
Save $90.10

 

9 hours ago | November 20, 2025

Prime members can secure a DJI Mini 4K drone for $239 in Amazon’s Black Friday sale. Mashable has reported about the potential for a ban on these drones, so this could be your best chance to grab one before it’s too late.

$239
at Amazon

$299
Save $60

 

10 hours ago | November 20, 2025

Best Buy was the first leading retailer to announce its 2025 holiday plans, with early Black Friday deals dropping as early as Halloween (Oct. 31). Best Buy’s official Black Friday sale kicks off on Nov. 20. This 10-day sale is live through Nov. 29, followed immediately by its Cyber Monday event on Nov. 30 that runs for 48 hours through Dec. 1.

Check out these heavy discounts on big-screen TVs at Best Buy:

10 hours ago | November 20, 2025

There are already so many stunning Apple deals at Amazon, but our favorite MacBook deal is still tough to beat. Right now, you can get the M4 MacBook Air, released earlier this year, for just $749.

23 hours ago | November 19, 2025

Brooklinen is already hosting a Black Friday sale, with 25% off its best sellers.

4:10 pm ET | November 19, 2025

3D printers aren’t new, but 2026 feels like the year that they’ll rise to a casual at-home hobby level. That’s mainly because super user-friendly (and affordable) 3D printers like the ones from Bambu Lab exist, and Best Buy has a handful of Bambu Lab 3D printers on sale at Black Friday pricing a week early. The Bambu Lab A1 Combo is widely regarded as the best 3D printer for most people, and you can grab it for $120 off.

$379.99
at Best Buy

$499.99
Save $120

 

3:00 pm ET | November 19, 2025

Best Buy and Amazon are set to kick off their official Black Friday sales tomorrow, Nov. 20. We’ll be digging through their sites to pick out the best deals for you.

2:30 pm ET | November 19, 2025

12:41 pm ET | November 19, 2025

12:03 pm ET | November 19, 2025

We’ve lined up the best early Black Friday speaker deals from our favorite brands. We recommend checking out the list in full, but for those in a hurry, here’s a quick snapshot of what’s on offer:

11:13 am ET | November 19, 2025

10:45 am ET | November 19, 2025

Our breakdown of the best early Black Friday headphones deals is live. Mashable’s expert Bethany Allard tests headphones for a living, and has picked five Black Friday deals worth your consideration. Read our roundup here.

10:12 am ET | November 19, 2025

We’re expecting Pokémon to be a big player over Black Friday 2025, but you don’t need to wait. A new Prismatic Evolution Premium Figure Collection is dropping at multiple retailers from Nov. 19 — here’s where to buy.

10:02 am ET | November 19, 2025

8:40 am ET | November 19, 2025

The 65-inch TCL QM6K QLED TV has hit its lowest-ever price on Amazon — pay under $500 ahead of Black Friday.

Mashable’s sister site PCMag reviewed this TV, saying “The TCL QM6K is a very good value and a strong performer for the price. While it isn’t the brightest TV available, its mini-LED backlight enables deep black levels for excellent contrast, its colors are wide and accurate, and it’s packed with features for streaming and gaming.” That’s more than enough for us, especially at this record-breaking price.

Read more here.

6:51 am ET | November 19, 2025

Black Friday deals don’t discriminate. You can find discounts on budget-friendly items under $10, and you can also find deals on big-ticket items like the latest tech from Apple. The new iPad Pro M5 is down to its best-ever price ahead of Black Friday — save over $70 at Amazon.

In Mashable’s review of the iPad Pro M5, Timothy Werth said this model is “a victory lap for Apple.”

6:37 am ET | November 19, 2025

Savvy shoppers are always seeking the biggest discounts over Black Friday, but you know what the savviest shoppers are doing at this time of year? Stocking up on freebies.

You can get three months of Amazon Music Unlimited for free as an early Black Friday treat. Once the promotional offer comes to an end, the plan will auto-renew at $11.99 per month for non-Prime members or $10.99 per month for Prime members. But you can cancel this automatic renewal at anytime, so you’ve got nothing to lose by signing up now.

6:31 am ET | November 19, 2025

Gifting for a Potterhead? The Lego Harry Potter Mandrake Figure is $29 off right now at Amazon.

Score this limited-time offer here. For more early Black Friday Lego deals, check out our breakdown of everything that’s already live here.

7:30 pm ET | November 19, 2025

Amazon’s official Black Friday sale doesn’t kick off until Nov. 20, but the retailer is still adding early deals on a daily basis. Case in point: This $250 discount on the Vitamix 5200 Professional-Grade Blender, its lowest sale price since 2022!

5:52 pm ET | November 18, 2025

On Nov. 18, we published a guide to early Black Friday deals on Advent calendars, with Christmas countdowns from Kiehl’s, Williams-Sonoma, Amazon, Sephora, Lego, and more. Check out some of our favorites, as the most popular calendars have a tendency to sell out.

5:30 pm ET | November 18, 2025

3:56 pm ET | November 18, 2025

We just published our guide to the best early Black Friday laptop deals, and so far MacBooks are leading the pack. However, you can also score a couple of great deals on Chromebooks, as well as our go-to gaming laptop. We don’t expect prices on these devices to get any lower, so if you need a new computer now, you can beat the crowds without worrying about missing a better deal next week.

  • Lenovo Flex 5i Chromebook Plus (Intel Core i3-1315U, 8GB RAM, 128GB SSD) — $349 $599 ($250)

  • Apple MacBook Air, 13-inch (M4, 16GB RAM, 256GB SSD) — $749.99 $999 (save $249.01)

  • Apple MacBook Air, 15-inch (M4, 16GB RAM, 256GB SSD) — $949.99 $1,149 (save $199.01)

  • Apple MacBook Air, 13-inch (M3, 8GB RAM, 256GB SSD) — $569.99 $849 (save $279.01) — Geek Squad Certified Refurbished

  • Alienware 16X Aurora (Intel Core Ultra 9 275HX, Nvidia GeForce RTX 5070, 32GB RAM, 1TB SSD) — $1,649.99 $1,999.99 (save $350)

3:39 pm ET | November 18, 2025

3:32 pm ET | November 18, 2025

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#Black #Friday #deals #Apple #Kindle #Ninja #sale

published late last week in the journal Nature Microbiology.

Good guy prions?

Prions are some of the strangest things around. They’re the misfolded form of a protein naturally found in the body. When a prion comes across its “normal” counterpart, it can somehow induce the latter to turn into a prion itself, almost like a zombie infection.

Classic prion disorders like mad cow disease and Creutzfeldt-Jakob disease are caused by the steady accumulation of one particular type of protein, aptly named the prion protein; these disorders are universally fatal. Some scientists have also argued that other neurodegenerative conditions, such as Alzheimer’s disease, are caused by other kinds of misfolded proteins that act in a similar way to prions.

According to the study researchers, there’s growing evidence that prions and prion-like proteins are more than just harbingers of death. Studies have found that the normal prion protein and the prion-like amyloid beta (one of the drivers of Alzheimer’s) can have antimicrobial activity, for instance. So the team decided to conduct a sweeping analysis looking for antimicrobial peptide fragments within these proteins.

The researchers had previously built an AI model intended to predict the antimicrobial activity of any given peptide fragment, named APEX 1.1. Then they let APEX scan through 19.3 million short peptide fragments found in 2,897 prion and prion-like proteins. They initially uncovered 1,179 candidates, which the team narrowed down to 75 that showed the most potential. Of these, 59 were able to inhibit the growth of at least one bacterial germ in the lab, including 42 that did so at low levels (important for dosing considerations).

Finally, the researchers tested two of the strongest candidates on the skin of mice infected with Acinetobacter baumannii, a common source of drug-resistant infections in people. The candidates appeared to be roughly as effective as polymyxin B, an existing antibiotic often used as a last resort drug for certain drug-resistant infections.

The researchers have coined these antibacterial fragments collected from prions as “prionins.”

The future of prionins

More research is obviously needed to verify whether the team’s prionins can actually work as hoped—and safely—in people. The researchers also note their findings don’t settle the open question as to whether prions or prion-like proteins naturally tackle bacterial infections in our body.

At the same time, they do argue their work provides a strong proof of concept that prionins identified through AI can be viable antibiotic candidates for further testing.

“For a long time, drug discovery has been limited not only by what we can test, but by where we choose to look,” said senior study author César de la Fuente, director of the Machine Biology Group at the University of Pennsylvania Perelman School of Medicine, in a statement from the university. “AI is changing that. It gives us a way to search the hidden layers of biology and ask whether molecules associated with one story—in this case, disease—may also carry another story with therapeutic potential.”

With any luck, the proteins known for causing the scariest diseases around could someday turn into our antibacterial allies.

#Deadly #Proteins #Mad #Cow #Disease #Fight #Superbugsantibiotic resistance,experimental drugs,prions">Deadly Proteins Behind Mad Cow Disease Might Help Us Fight Superbugs
                The next frontier of antibiotics might come from an unexpected place. Recent research identifies potential antibiotic candidates from inside prions—proteins capable of causing some of the deadliest brain infections ever known, such as mad cow disease.

 Scientists at the University of Pennsylvania used artificial intelligence to rapidly search hundreds of prions and prion-like proteins for peptides with antibacterial activity. They found several dozen promising candidates, two of which have already shown results treating bacterial infections in mice. The team’s findings establish “prion-related proteins as a productive source space for antibiotic discovery,” the scientists wrote in their paper, published late last week in the journal Nature Microbiology.

 Good guy prions? Prions are some of the strangest things around. They’re the misfolded form of a protein naturally found in the body. When a prion comes across its “normal” counterpart, it can somehow induce the latter to turn into a prion itself, almost like a zombie infection.

 Classic prion disorders like mad cow disease and Creutzfeldt-Jakob disease are caused by the steady accumulation of one particular type of protein, aptly named the prion protein; these disorders are universally fatal. Some scientists have also argued that other neurodegenerative conditions, such as Alzheimer’s disease, are caused by other kinds of misfolded proteins that act in a similar way to prions.   According to the study researchers, there’s growing evidence that prions and prion-like proteins are more than just harbingers of death. Studies have found that the normal prion protein and the prion-like amyloid beta (one of the drivers of Alzheimer’s) can have antimicrobial activity, for instance. So the team decided to conduct a sweeping analysis looking for antimicrobial peptide fragments within these proteins.

 The researchers had previously built an AI model intended to predict the antimicrobial activity of any given peptide fragment, named APEX 1.1. Then they let APEX scan through 19.3 million short peptide fragments found in 2,897 prion and prion-like proteins. They initially uncovered 1,179 candidates, which the team narrowed down to 75 that showed the most potential. Of these, 59 were able to inhibit the growth of at least one bacterial germ in the lab, including 42 that did so at low levels (important for dosing considerations). Finally, the researchers tested two of the strongest candidates on the skin of mice infected with Acinetobacter baumannii, a common source of drug-resistant infections in people. The candidates appeared to be roughly as effective as polymyxin B, an existing antibiotic often used as a last resort drug for certain drug-resistant infections. The researchers have coined these antibacterial fragments collected from prions as “prionins.”

 The future of prionins More research is obviously needed to verify whether the team’s prionins can actually work as hoped—and safely—in people. The researchers also note their findings don’t settle the open question as to whether prions or prion-like proteins naturally tackle bacterial infections in our body. At the same time, they do argue their work provides a strong proof of concept that prionins identified through AI can be viable antibiotic candidates for further testing. “For a long time, drug discovery has been limited not only by what we can test, but by where we choose to look,” said senior study author César de la Fuente, director of the Machine Biology Group at the University of Pennsylvania Perelman School of Medicine, in a statement from the university. “AI is changing that. It gives us a way to search the hidden layers of biology and ask whether molecules associated with one story—in this case, disease—may also carry another story with therapeutic potential.”

 With any luck, the proteins known for causing the scariest diseases around could someday turn into our antibacterial allies.      #Deadly #Proteins #Mad #Cow #Disease #Fight #Superbugsantibiotic resistance,experimental drugs,prions

published late last week in the journal Nature Microbiology.

Good guy prions?

Prions are some of the strangest things around. They’re the misfolded form of a protein naturally found in the body. When a prion comes across its “normal” counterpart, it can somehow induce the latter to turn into a prion itself, almost like a zombie infection.

Classic prion disorders like mad cow disease and Creutzfeldt-Jakob disease are caused by the steady accumulation of one particular type of protein, aptly named the prion protein; these disorders are universally fatal. Some scientists have also argued that other neurodegenerative conditions, such as Alzheimer’s disease, are caused by other kinds of misfolded proteins that act in a similar way to prions.

According to the study researchers, there’s growing evidence that prions and prion-like proteins are more than just harbingers of death. Studies have found that the normal prion protein and the prion-like amyloid beta (one of the drivers of Alzheimer’s) can have antimicrobial activity, for instance. So the team decided to conduct a sweeping analysis looking for antimicrobial peptide fragments within these proteins.

The researchers had previously built an AI model intended to predict the antimicrobial activity of any given peptide fragment, named APEX 1.1. Then they let APEX scan through 19.3 million short peptide fragments found in 2,897 prion and prion-like proteins. They initially uncovered 1,179 candidates, which the team narrowed down to 75 that showed the most potential. Of these, 59 were able to inhibit the growth of at least one bacterial germ in the lab, including 42 that did so at low levels (important for dosing considerations).

Finally, the researchers tested two of the strongest candidates on the skin of mice infected with Acinetobacter baumannii, a common source of drug-resistant infections in people. The candidates appeared to be roughly as effective as polymyxin B, an existing antibiotic often used as a last resort drug for certain drug-resistant infections.

The researchers have coined these antibacterial fragments collected from prions as “prionins.”

The future of prionins

More research is obviously needed to verify whether the team’s prionins can actually work as hoped—and safely—in people. The researchers also note their findings don’t settle the open question as to whether prions or prion-like proteins naturally tackle bacterial infections in our body.

At the same time, they do argue their work provides a strong proof of concept that prionins identified through AI can be viable antibiotic candidates for further testing.

“For a long time, drug discovery has been limited not only by what we can test, but by where we choose to look,” said senior study author César de la Fuente, director of the Machine Biology Group at the University of Pennsylvania Perelman School of Medicine, in a statement from the university. “AI is changing that. It gives us a way to search the hidden layers of biology and ask whether molecules associated with one story—in this case, disease—may also carry another story with therapeutic potential.”

With any luck, the proteins known for causing the scariest diseases around could someday turn into our antibacterial allies.

#Deadly #Proteins #Mad #Cow #Disease #Fight #Superbugsantibiotic resistance,experimental drugs,prions">Deadly Proteins Behind Mad Cow Disease Might Help Us Fight SuperbugsDeadly Proteins Behind Mad Cow Disease Might Help Us Fight Superbugs
                The next frontier of antibiotics might come from an unexpected place. Recent research identifies potential antibiotic candidates from inside prions—proteins capable of causing some of the deadliest brain infections ever known, such as mad cow disease.

 Scientists at the University of Pennsylvania used artificial intelligence to rapidly search hundreds of prions and prion-like proteins for peptides with antibacterial activity. They found several dozen promising candidates, two of which have already shown results treating bacterial infections in mice. The team’s findings establish “prion-related proteins as a productive source space for antibiotic discovery,” the scientists wrote in their paper, published late last week in the journal Nature Microbiology.

 Good guy prions? Prions are some of the strangest things around. They’re the misfolded form of a protein naturally found in the body. When a prion comes across its “normal” counterpart, it can somehow induce the latter to turn into a prion itself, almost like a zombie infection.

 Classic prion disorders like mad cow disease and Creutzfeldt-Jakob disease are caused by the steady accumulation of one particular type of protein, aptly named the prion protein; these disorders are universally fatal. Some scientists have also argued that other neurodegenerative conditions, such as Alzheimer’s disease, are caused by other kinds of misfolded proteins that act in a similar way to prions.   According to the study researchers, there’s growing evidence that prions and prion-like proteins are more than just harbingers of death. Studies have found that the normal prion protein and the prion-like amyloid beta (one of the drivers of Alzheimer’s) can have antimicrobial activity, for instance. So the team decided to conduct a sweeping analysis looking for antimicrobial peptide fragments within these proteins.

 The researchers had previously built an AI model intended to predict the antimicrobial activity of any given peptide fragment, named APEX 1.1. Then they let APEX scan through 19.3 million short peptide fragments found in 2,897 prion and prion-like proteins. They initially uncovered 1,179 candidates, which the team narrowed down to 75 that showed the most potential. Of these, 59 were able to inhibit the growth of at least one bacterial germ in the lab, including 42 that did so at low levels (important for dosing considerations). Finally, the researchers tested two of the strongest candidates on the skin of mice infected with Acinetobacter baumannii, a common source of drug-resistant infections in people. The candidates appeared to be roughly as effective as polymyxin B, an existing antibiotic often used as a last resort drug for certain drug-resistant infections. The researchers have coined these antibacterial fragments collected from prions as “prionins.”

 The future of prionins More research is obviously needed to verify whether the team’s prionins can actually work as hoped—and safely—in people. The researchers also note their findings don’t settle the open question as to whether prions or prion-like proteins naturally tackle bacterial infections in our body. At the same time, they do argue their work provides a strong proof of concept that prionins identified through AI can be viable antibiotic candidates for further testing. “For a long time, drug discovery has been limited not only by what we can test, but by where we choose to look,” said senior study author César de la Fuente, director of the Machine Biology Group at the University of Pennsylvania Perelman School of Medicine, in a statement from the university. “AI is changing that. It gives us a way to search the hidden layers of biology and ask whether molecules associated with one story—in this case, disease—may also carry another story with therapeutic potential.”

 With any luck, the proteins known for causing the scariest diseases around could someday turn into our antibacterial allies.      #Deadly #Proteins #Mad #Cow #Disease #Fight #Superbugsantibiotic resistance,experimental drugs,prions

The next frontier of antibiotics might come from an unexpected place. Recent research identifies potential antibiotic candidates from inside prions—proteins capable of causing some of the deadliest brain infections ever known, such as mad cow disease.

Scientists at the University of Pennsylvania used artificial intelligence to rapidly search hundreds of prions and prion-like proteins for peptides with antibacterial activity. They found several dozen promising candidates, two of which have already shown results treating bacterial infections in mice.

The team’s findings establish “prion-related proteins as a productive source space for antibiotic discovery,” the scientists wrote in their paper, published late last week in the journal Nature Microbiology.

Good guy prions?

Prions are some of the strangest things around. They’re the misfolded form of a protein naturally found in the body. When a prion comes across its “normal” counterpart, it can somehow induce the latter to turn into a prion itself, almost like a zombie infection.

Classic prion disorders like mad cow disease and Creutzfeldt-Jakob disease are caused by the steady accumulation of one particular type of protein, aptly named the prion protein; these disorders are universally fatal. Some scientists have also argued that other neurodegenerative conditions, such as Alzheimer’s disease, are caused by other kinds of misfolded proteins that act in a similar way to prions.

According to the study researchers, there’s growing evidence that prions and prion-like proteins are more than just harbingers of death. Studies have found that the normal prion protein and the prion-like amyloid beta (one of the drivers of Alzheimer’s) can have antimicrobial activity, for instance. So the team decided to conduct a sweeping analysis looking for antimicrobial peptide fragments within these proteins.

The researchers had previously built an AI model intended to predict the antimicrobial activity of any given peptide fragment, named APEX 1.1. Then they let APEX scan through 19.3 million short peptide fragments found in 2,897 prion and prion-like proteins. They initially uncovered 1,179 candidates, which the team narrowed down to 75 that showed the most potential. Of these, 59 were able to inhibit the growth of at least one bacterial germ in the lab, including 42 that did so at low levels (important for dosing considerations).

Finally, the researchers tested two of the strongest candidates on the skin of mice infected with Acinetobacter baumannii, a common source of drug-resistant infections in people. The candidates appeared to be roughly as effective as polymyxin B, an existing antibiotic often used as a last resort drug for certain drug-resistant infections.

The researchers have coined these antibacterial fragments collected from prions as “prionins.”

The future of prionins

More research is obviously needed to verify whether the team’s prionins can actually work as hoped—and safely—in people. The researchers also note their findings don’t settle the open question as to whether prions or prion-like proteins naturally tackle bacterial infections in our body.

At the same time, they do argue their work provides a strong proof of concept that prionins identified through AI can be viable antibiotic candidates for further testing.

“For a long time, drug discovery has been limited not only by what we can test, but by where we choose to look,” said senior study author César de la Fuente, director of the Machine Biology Group at the University of Pennsylvania Perelman School of Medicine, in a statement from the university. “AI is changing that. It gives us a way to search the hidden layers of biology and ask whether molecules associated with one story—in this case, disease—may also carry another story with therapeutic potential.”

With any luck, the proteins known for causing the scariest diseases around could someday turn into our antibacterial allies.

#Deadly #Proteins #Mad #Cow #Disease #Fight #Superbugsantibiotic resistance,experimental drugs,prions

PS Svarva Floor Lamp

“Some stuff I did myself, like this one. The Svarva lamp we made with the design group Front for the PS 2009 collection. They were quite newly established and so we did an armchair and this lamp. The desire was to do a wooden turned lamp, but you should also be able to twist it, articulate it.”

“I felt that that would be very difficult to do. Along with a colleague in lighting at the time, I went to Hungary to this factory that was producing lamps for us. It was all metal tubes that they were doing, so we were a little bit hesitant whether they should be able to solve this. But they made some mock-ups based on the designer drawings. So we went there to have a look, and it was standing there. It was this floor lamp, and also a table lamp where the wooden beads were going in a circle and then up, like a snake.”

“What we didn’t know was that next to the lamp factory was this factory that was doing the turned wooden beads, the small individual pieces that we put together. None of us knew that. It was just pure serendipity. So they were turning these wooden beads, and the lamp factory was putting them on the metal tubes, just like on a necklace. They had very little to do, so they were happy to get the business.”

Image may contain Furniture Home Decor Rug Clothing Footwear Shoe and Chest Of Drawers

A Sinka Cabinet resides in Ejdemo’s hallway.

Courtesy of Johan Ejdemo

PS Sinka Cabinet

“I have another favorite from that PS 2009 collection, it’s in my hallway. The PS Sinka, with the small drawers with a wooden base. Sinka means “dovetail” in Swedish, so the name explaining that construction.”

“But the problem we had with this one was the packaging volume was too big. So what we did was each drawer is slightly shallower. So four drawers stack into each other. And four more drawers stack. There’s a little bit of a stopper in the back when you push them in, so they stop evenly at the front. There’s also a hidden compartment behind the smallest drawer. Really good drawers for all this stuff that is just lying around and getting in the way. In the top one I have all my keys that I no longer know where they go.”

PS Jonsberg Vases

“I have this vase from the PS collection to hold the cables [on my Samsung Serif TV]. It was a set, the Jonsberg vases by Hella Jongerius. There were four of them in different ceramic techniques. I had all four, but the terracotta one broke, which was a pity.” [It certainly is. These $39 vases now sell secondhand for $1,700 for a full set.]

“They’re inspired by different regions, and the different techniques are beautiful. I use the big black one for toilet paper in one bathroom. It’s not disrespect for the design. It’s just such a good design to stand there, and it makes the bathroom beautiful, and it can fit the toilet roll. So, why have something like an ugly stick? It’s nice for that.”

Pax Wardrobes

“Pax. We have to mention Pax. I have Pax wardrobes in a few rooms, but also I’m a little bit peculiar. Like in the kitchen, these veneer doors have been sanded and hand-painted by me, just to make them fit my house, in my space. I repaint them sometimes.”

Chipped Spraka pepper mills.

Chipped Spraka pepper mills.

Courtesy of Johan Ejdemo

Spraka Pepper Mills

“I have these pepper mills. One for white pepper, one for black pepper. That was also in a PS collection. We did these with Marcus Arvonen. These pepper mills are beautiful, and these have been around for, like, 20 years as well. They are pretty tall. A smaller version came later on, but I like these.”

“They have their chips, yes, but this just makes them nicer. It’s age. They’ve been around and are used every day. Everything has a little bit of imperfection. You can spend your whole life bothering about that, but there should be some imperfection in life. Fix it? Then something else needs fixing. It just moves. Leave it, be proud.”

Where’s the Billy Bookcase or Kallax?

“I don’t have a Billy in the house now. But there have been! Kallax? I have owned many. Brilliant piece. Really good for vinyl, because that’s the time they come from. I listen to a lot of vinyl.”

#Ikea #Products #Companys #Design #Chief #Personally #Ownsikea,design,home,furniture,household,interviews">These Are the 12 Ikea Products the Company’s Design Chief Personally OwnsThe Svarva lamp can be twisted into different shapes.
Courtesy of Johan EjdemoPS Svarva Floor Lamp“Some stuff I did myself, like this one. The Svarva lamp we made with the design group Front for the PS 2009 collection. They were quite newly established and so we did an armchair and this lamp. The desire was to do a wooden turned lamp, but you should also be able to twist it, articulate it.”“I felt that that would be very difficult to do. Along with a colleague in lighting at the time, I went to Hungary to this factory that was producing lamps for us. It was all metal tubes that they were doing, so we were a little bit hesitant whether they should be able to solve this. But they made some mock-ups based on the designer drawings. So we went there to have a look, and it was standing there. It was this floor lamp, and also a table lamp where the wooden beads were going in a circle and then up, like a snake.”“What we didn’t know was that next to the lamp factory was this factory that was doing the turned wooden beads, the small individual pieces that we put together. None of us knew that. It was just pure serendipity. So they were turning these wooden beads, and the lamp factory was putting them on the metal tubes, just like on a necklace. They had very little to do, so they were happy to get the business.”A Sinka Cabinet resides in Ejdemo’s hallway.
Courtesy of Johan EjdemoPS Sinka Cabinet“I have another favorite from that PS 2009 collection, it’s in my hallway. The PS Sinka, with the small drawers with a wooden base. Sinka means “dovetail” in Swedish, so the name explaining that construction.”“But the problem we had with this one was the packaging volume was too big. So what we did was each drawer is slightly shallower. So four drawers stack into each other. And four more drawers stack. There’s a little bit of a stopper in the back when you push them in, so they stop evenly at the front. There’s also a hidden compartment behind the smallest drawer. Really good drawers for all this stuff that is just lying around and getting in the way. In the top one I have all my keys that I no longer know where they go.”PS Jonsberg Vases“I have this vase from the PS collection to hold the cables [on my Samsung Serif TV]. It was a set, the Jonsberg vases by Hella Jongerius. There were four of them in different ceramic techniques. I had all four, but the terracotta one broke, which was a pity.” [It certainly is. These  vases now sell secondhand for ,700 for a full set.]“They’re inspired by different regions, and the different techniques are beautiful. I use the big black one for toilet paper in one bathroom. It’s not disrespect for the design. It’s just such a good design to stand there, and it makes the bathroom beautiful, and it can fit the toilet roll. So, why have something like an ugly stick? It’s nice for that.”Pax Wardrobes“Pax. We have to mention Pax. I have Pax wardrobes in a few rooms, but also I’m a little bit peculiar. Like in the kitchen, these veneer doors have been sanded and hand-painted by me, just to make them fit my house, in my space. I repaint them sometimes.”Chipped Spraka pepper mills.
Courtesy of Johan EjdemoSpraka Pepper Mills“I have these pepper mills. One for white pepper, one for black pepper. That was also in a PS collection. We did these with Marcus Arvonen. These pepper mills are beautiful, and these have been around for, like, 20 years as well. They are pretty tall. A smaller version came later on, but I like these.”“They have their chips, yes, but this just makes them nicer. It’s age. They’ve been around and are used every day. Everything has a little bit of imperfection. You can spend your whole life bothering about that, but there should be some imperfection in life. Fix it? Then something else needs fixing. It just moves. Leave it, be proud.”Where’s the Billy Bookcase or Kallax?“I don’t have a Billy in the house now. But there have been! Kallax? I have owned many. Brilliant piece. Really good for vinyl, because that’s the time they come from. I listen to a lot of vinyl.”#Ikea #Products #Companys #Design #Chief #Personally #Ownsikea,design,home,furniture,household,interviews

Svarva lamp we made with the design group Front for the PS 2009 collection. They were quite newly established and so we did an armchair and this lamp. The desire was to do a wooden turned lamp, but you should also be able to twist it, articulate it.”

“I felt that that would be very difficult to do. Along with a colleague in lighting at the time, I went to Hungary to this factory that was producing lamps for us. It was all metal tubes that they were doing, so we were a little bit hesitant whether they should be able to solve this. But they made some mock-ups based on the designer drawings. So we went there to have a look, and it was standing there. It was this floor lamp, and also a table lamp where the wooden beads were going in a circle and then up, like a snake.”

“What we didn’t know was that next to the lamp factory was this factory that was doing the turned wooden beads, the small individual pieces that we put together. None of us knew that. It was just pure serendipity. So they were turning these wooden beads, and the lamp factory was putting them on the metal tubes, just like on a necklace. They had very little to do, so they were happy to get the business.”

Image may contain Furniture Home Decor Rug Clothing Footwear Shoe and Chest Of Drawers

A Sinka Cabinet resides in Ejdemo’s hallway.

Courtesy of Johan Ejdemo

PS Sinka Cabinet

“I have another favorite from that PS 2009 collection, it’s in my hallway. The PS Sinka, with the small drawers with a wooden base. Sinka means “dovetail” in Swedish, so the name explaining that construction.”

“But the problem we had with this one was the packaging volume was too big. So what we did was each drawer is slightly shallower. So four drawers stack into each other. And four more drawers stack. There’s a little bit of a stopper in the back when you push them in, so they stop evenly at the front. There’s also a hidden compartment behind the smallest drawer. Really good drawers for all this stuff that is just lying around and getting in the way. In the top one I have all my keys that I no longer know where they go.”

PS Jonsberg Vases

“I have this vase from the PS collection to hold the cables [on my Samsung Serif TV]. It was a set, the Jonsberg vases by Hella Jongerius. There were four of them in different ceramic techniques. I had all four, but the terracotta one broke, which was a pity.” [It certainly is. These $39 vases now sell secondhand for $1,700 for a full set.]

“They’re inspired by different regions, and the different techniques are beautiful. I use the big black one for toilet paper in one bathroom. It’s not disrespect for the design. It’s just such a good design to stand there, and it makes the bathroom beautiful, and it can fit the toilet roll. So, why have something like an ugly stick? It’s nice for that.”

Pax Wardrobes

“Pax. We have to mention Pax. I have Pax wardrobes in a few rooms, but also I’m a little bit peculiar. Like in the kitchen, these veneer doors have been sanded and hand-painted by me, just to make them fit my house, in my space. I repaint them sometimes.”

Chipped Spraka pepper mills.

Chipped Spraka pepper mills.

Courtesy of Johan Ejdemo

Spraka Pepper Mills

“I have these pepper mills. One for white pepper, one for black pepper. That was also in a PS collection. We did these with Marcus Arvonen. These pepper mills are beautiful, and these have been around for, like, 20 years as well. They are pretty tall. A smaller version came later on, but I like these.”

“They have their chips, yes, but this just makes them nicer. It’s age. They’ve been around and are used every day. Everything has a little bit of imperfection. You can spend your whole life bothering about that, but there should be some imperfection in life. Fix it? Then something else needs fixing. It just moves. Leave it, be proud.”

Where’s the Billy Bookcase or Kallax?

“I don’t have a Billy in the house now. But there have been! Kallax? I have owned many. Brilliant piece. Really good for vinyl, because that’s the time they come from. I listen to a lot of vinyl.”

#Ikea #Products #Companys #Design #Chief #Personally #Ownsikea,design,home,furniture,household,interviews">These Are the 12 Ikea Products the Company’s Design Chief Personally Owns
Image may contain Lamp Chair Furniture Art Painting and Floor Lamp

The Svarva lamp can be twisted into different shapes.

Courtesy of Johan Ejdemo

PS Svarva Floor Lamp

“Some stuff I did myself, like this one. The Svarva lamp we made with the design group Front for the PS 2009 collection. They were quite newly established and so we did an armchair and this lamp. The desire was to do a wooden turned lamp, but you should also be able to twist it, articulate it.”

“I felt that that would be very difficult to do. Along with a colleague in lighting at the time, I went to Hungary to this factory that was producing lamps for us. It was all metal tubes that they were doing, so we were a little bit hesitant whether they should be able to solve this. But they made some mock-ups based on the designer drawings. So we went there to have a look, and it was standing there. It was this floor lamp, and also a table lamp where the wooden beads were going in a circle and then up, like a snake.”

“What we didn’t know was that next to the lamp factory was this factory that was doing the turned wooden beads, the small individual pieces that we put together. None of us knew that. It was just pure serendipity. So they were turning these wooden beads, and the lamp factory was putting them on the metal tubes, just like on a necklace. They had very little to do, so they were happy to get the business.”

Image may contain Furniture Home Decor Rug Clothing Footwear Shoe and Chest Of Drawers

A Sinka Cabinet resides in Ejdemo’s hallway.

Courtesy of Johan Ejdemo

PS Sinka Cabinet

“I have another favorite from that PS 2009 collection, it’s in my hallway. The PS Sinka, with the small drawers with a wooden base. Sinka means “dovetail” in Swedish, so the name explaining that construction.”

“But the problem we had with this one was the packaging volume was too big. So what we did was each drawer is slightly shallower. So four drawers stack into each other. And four more drawers stack. There’s a little bit of a stopper in the back when you push them in, so they stop evenly at the front. There’s also a hidden compartment behind the smallest drawer. Really good drawers for all this stuff that is just lying around and getting in the way. In the top one I have all my keys that I no longer know where they go.”

PS Jonsberg Vases

“I have this vase from the PS collection to hold the cables [on my Samsung Serif TV]. It was a set, the Jonsberg vases by Hella Jongerius. There were four of them in different ceramic techniques. I had all four, but the terracotta one broke, which was a pity.” [It certainly is. These $39 vases now sell secondhand for $1,700 for a full set.]

“They’re inspired by different regions, and the different techniques are beautiful. I use the big black one for toilet paper in one bathroom. It’s not disrespect for the design. It’s just such a good design to stand there, and it makes the bathroom beautiful, and it can fit the toilet roll. So, why have something like an ugly stick? It’s nice for that.”

Pax Wardrobes

“Pax. We have to mention Pax. I have Pax wardrobes in a few rooms, but also I’m a little bit peculiar. Like in the kitchen, these veneer doors have been sanded and hand-painted by me, just to make them fit my house, in my space. I repaint them sometimes.”

Chipped Spraka pepper mills.

Chipped Spraka pepper mills.

Courtesy of Johan Ejdemo

Spraka Pepper Mills

“I have these pepper mills. One for white pepper, one for black pepper. That was also in a PS collection. We did these with Marcus Arvonen. These pepper mills are beautiful, and these have been around for, like, 20 years as well. They are pretty tall. A smaller version came later on, but I like these.”

“They have their chips, yes, but this just makes them nicer. It’s age. They’ve been around and are used every day. Everything has a little bit of imperfection. You can spend your whole life bothering about that, but there should be some imperfection in life. Fix it? Then something else needs fixing. It just moves. Leave it, be proud.”

Where’s the Billy Bookcase or Kallax?

“I don’t have a Billy in the house now. But there have been! Kallax? I have owned many. Brilliant piece. Really good for vinyl, because that’s the time they come from. I listen to a lot of vinyl.”

#Ikea #Products #Companys #Design #Chief #Personally #Ownsikea,design,home,furniture,household,interviews

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