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Amazon Black Friday 2025: The sale is officially live, and we handpicked 150+ of the best deals

Amazon Black Friday 2025: The sale is officially live, and we handpicked 150+ of the best deals

Black Friday falls on Nov. 28 this year, but that doesn’t mean you need to wait until after pumpkin pie to shop. Amazon’s official Black Friday sale has been underway since Nov. 20, and we’re seeing a bunch of epic deals. Some of our favorite products from Bose, Apple, Anker, and Lego are on sale, in addition to Amazon devices like Kindles and the Echo lineup, plus discounts on some of our favorite gifts for 2025.

A majority of Amazon Black Friday deals are record-low prices that match or beat the deals we saw during October Prime Day. See the evidence for yourself by plugging the URL into camelcamelcamel, the Mashable shopping team’s secret weapon to finding the lowest prices at Amazon.

SEE ALSO:

20+ of the best Black Friday streaming deals live: HBO Max, Apple TV+, Spotify, and more

With speedy Prime shipping, shopping Amazon’s sale early could get some of your items to your doorstep before Thanksgiving even starts.

Recommended deals for you

Apple AirPods Pro 3 Noise Cancelling Heart Rate Wireless Earbuds


$219.99

(List Price $249.00)

Apple iPad 11″ 128GB Wi-Fi Retina Tablet (Blue, 2025 Release)


$274.00

(List Price $349.00)

Amazon Fire HD 10 32GB Tablet (2023 Release, Black)


$69.99

(List Price $139.99)

Sony WH-1000XM5 Wireless Noise Canceling Headphones


$248.00

(List Price $399.99)

Blink Outdoor 4 1080p Security Camera (5-Pack)


$159.99

(List Price $399.99)

Fire TV Stick 4K Streaming Device With Remote (2023 Model)


$24.99

(List Price $49.99)

Bose Quiet Comfort Ultra Wireless Noise Cancelling Headphones


$298.00

(List Price $429.00)

Shark AV2511AE AI Robot Vacuum With XL Self-Empty Base


$249.99

(List Price $599.00)

Apple Watch Series 11 (GPS, 42mm, S/M Black Sport Band)


$339.00

(List Price $399.00)

WD 6TB My Passport USB 3.0 Portable External Hard Drive


$134.99

(List Price $179.99)

We’ll be updating this page with new Amazon Black Friday deals as they drop, so keep checking back through the end of Cyber Weekend. Of course, it’s worth checking out the best deals from competing retailers like Target, Best Buy, and Walmart to make sure you’re getting the best deal (we curate our lists to only include deals that are the actual best ones across retailers). If you don’t feel like scrolling through all of that, you can keep up with the utmost best deals across the internet with our live deals tracker or get them texted straight to your phone.

Best Apple deal

$479
at Amazon

$599
Save $120

 

Why we like it

If you need a desktop upgrade, this is hands-down the best value you can get right now. The new Mac mini packs the M4 chip into a tiny 5-inch box, and Apple finally upped the starting RAM to 16GB (instead of the stingy 8GB of the past). That means it can actually handle heavy multitasking right out of the box.

Honorable mention: Apple deals are going hard this Black Friday. The AirPods 4 with ANC just hit a record-low price of $99.99, but they’re flying off the shelves. We’ve seen them sell out once at Amazon already, so if they’re sold out for you, you can also grab them for $99.99 at Target. These give the entry-level AirPods (currently on sale for $69.99) the nice addition of ANC, which performed so well that it earned these buds a coveted Mashable Choice Award.

Read Mashable’s full review of the Apple AirPods 4 with ANC.

More Black Friday Apple deals at Amazon

  • Apple AirTag — $17.97 $29 (save $11.03)

  • Apple AirTag (4-pack) — $64.98 $99 (save $34.02)

  • Apple Pencil (USB-C) — $69 $79 (save $10)

  • Apple Pencil Pro — $99 $129 (save $30)

  • Apple iPad, 11-inch (A16, WiFi, 128GB) — $279 $349 (save $70)

  • Apple iPad mini (A17 Pro, WiFi, 128GB) — $399 $499 (save $100)

  • Apple iPad, 11-inch (A16, WiFi + cellular, 128GB) — $429 $499 (save $70)

  • Apple AirPods 4 — $69 $129 (save $60)

  • Apple AirPods Pro 3 — $219.99 $249 (save $19.01)

  • Apple AirPods Max (USB-C) — $399.99 $549 (save $149.01)

  • Apple iPad Air, 11-inch (M3, WiFi, 128GB) — $449 $599 (save $150)

  • Apple Mac mini (M4, 16GB RAM, 256GB SSD) — $479 $599 (save $120)

  • Apple iPad Air, 13-inch (M3, WiFi, 128GB) — $649 $799 (save $50)

  • Apple iPad Pro (M5, 11 inch) — $899 $999 (save $100)

  • Apple MacBook Air, 13-inch (M4, 16GB RAM, 512GB SSD) — $949 $1,199 (save $250)

  • Apple MacBook Air, 15-inch (M4, 16GB RAM, 256GB SSD) — $949 $1,199 (save $250)

  • Apple MacBook Pro, 14-inch (M5, 16GB RAM, 512GB SSD) — $1,444 $1,599 (save $250)

  • Apple MacBook Air, 13-inch (M4, 24GB RAM, 512GB SSD) — $1,149 $1,399 (save $200)

Best Lego deal

$50.99
at Amazon

$79.99
Save $29.00

 

Why we like it

As the year comes to a close, another heartbreaking handful of Legos are set to retire. The Mos Espa Podrace dioarama from The Phantom Menace is one of them, so now is your last chance not only to find it in stock at all, but for nearly $20 off its usual price. This set is a best-seller for a reason: You get the full canyon in Tattooine scene, models of both Anakin’s Podracer and Subulba’s Podracer, and a special 25th anniversary plaque with a quote from Qui-Gon Jinn. It’s nostalgia in brick form that any Star Wars fan should have in their collection.

More early Black Friday Lego deals

Best Kindle deal

$124
at Amazon

$159
Save $35

 

Why we like it

Down at a record-low price, the Amazon Kindle Paperwhite is Mashable’s favorite Kindle. It can get up to 12 weeks of battery life before you’ll need to recharge, and the 16GB storage gives plenty of room for downloaded books. Gift it to the reader in your life or snag one for yourself to stay entertained during holiday travel. It’s also fully waterproof, so you can take it along to the pool or on your tropical winter vacation.

More Kindle deals

Best Amazon device deal

Amazon Echo Pop | Full sound compact smart speaker with Alexa | Glacier White

$21.99
at Amazon

$39.99
Save $18.00

 

Why we like it

Read Mashable’s full review of the Echo Pop.

It’s a known fact of the universe that Amazon devices get serious discounts on Black Friday (and Prime Day, for that matter). If you haven’t picked up a smart speaker yet, or just need one for a random room like the laundry room or guest bath, we recommend the Echo Pop. It’s currently $21.99, which is 45% off its regular price. Unlike the spherical Echo Dot, the Pop has a flat front that makes it fit way better on shallow shelves or crowded nightstands. It’s the perfect low-stakes way to add Alexa to another corner of your house without spending “real” money.

More early Black Friday Amazon device deals

Best portable power station deal

$349
at Amazon

$799
Save $450

 

Why we like it

Read Mashable’s full review of the Anker Solix C1000 Gen 2.

The new Anker Solix C1000 Gen 2 is one of my favorite portable power stations to hit the market this year. Anker’s new Gen 2 models focus on portability, and the C1000 Gen 2 is shockingly easy to carry around at 25 pounds. It’s a great model for taking to the campground or keeping in the garage in case of power outages. Thanks to Amazon’s Black Friday sale, this model is down to a new record low.

More Black Friday portable power station deals

Best headphones deal

Why we like it

Read Mashable’s full review of the Bose QuietComfort Ultra headphones (2nd Gen).

If you’re looking for the most comfortable noise-cancelling headphones on the market, you want the Bose QuietComfort Ultra. As long as you’re cool with black or white, they’re on sale for $298. Since we spend plenty of the day listening to music, podcasts, or streaming YouTube, there’s good reason to invest in a super comfortable pair. Of course, they’ll make for a special gift this holiday season, or consider it a gift of self-care to get yourself through holiday travel.

More Black Friday headphones deals

Best smartwatch deal

$199.99
at Amazon

$249
Save $49.01

 

Why we like it

The Apple Watch SE 3 earns the top spot on Mashable’s list of the best smartwatches. The SE 3 is the first SE model to come with an always-on display. Mashable Tech Editor Timothy Beck Werth wrote, “In addition to its gorgeous OLED display, it has the same S10 chip inside the Ultra 3, the same water resistance as the Series 11, and all the necessary features you’re looking for in a smartwatch.” All of that now comes in at under $200 thanks to this Black Friday sale at Amazon.

More early Black Friday smartwatch deals

Black Friday TV deals at Amazon

Insignia 75

$399.99
at Amazon

$649.99
Save $250

 

Why we like it

When you think of TVs on sale at Amazon, you probably think of Amazon’s own Fire TVs. You’re half right: The best Fire TV deal at Amazon is a Fire TV, but it’s actually Insignia (a Best Buy brand). At just $399.99 after a 38% discount, this 75-inch Insignia QLED is the cheapest 75-inch QLED TV we’ve seen across all Black Friday TV deals so far — that’s almost $200 cheaper than the non-QLED 75-inch version of Amazon’s Omni TV. And why would you settle when you could bring home the boosted quantum dot brightness for watching in the daytime?

Mashable Deals

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More Black Friday TV deals

43-inch TVs

50- to 55-inch TVs

65-inch TVs

75-inch TVs and up

85-inch TVs and up

Black Friday robot vacuum deals at Amazon

Roborock Saros 10R Self-Emptying Robot Vacuum and Mop (Black)

$999.99
at Amazon

$1,599.99
Save $600

 

Why we like it

This Black Friday season marks the very first time the Roborock Saros 10R has dropped below $1,000, so senior shopping reporter Leah Stodart can’t help but recommend it to people — considering the Saros 10R was her favorite robot vacuum that she’s ever tested for most of 2025, and is still the best robot vacuum mop combo when it comes to corner and edge mopping. (In Reddit threads about which robot vacuum everyone is looking to buy this Black Friday, the Saros 10R is mentioned multiple times.)

At 22,000 Pa of suction power, the Saros 10R is also one of the most powerful robot vacs you’ll find on sale this season. Plus, the livestream pet camera will quickly become a daily staple in the routines of busy pet parents.

More Black Friday robot vacuum deals

Robot vacuum and mop combos

Robot vacuums that don’t mop

Black Friday kitchen deals

Ninja SLUSHi Professional Frozen Drink Maker with RapidChill Technology, 88 oz. Frozen Drink & Slushie Machine, 5 Preset Programs, Frozen Margaritas, Frappés, and More, Margarita, FS301TG

$269.99
at Amazon

$369.99
Save $100

 

Why we like it

The Ninja Slushi is a blast in any season — frozen margs in any flavor you want when it’s hot, apple cider slush or gingerbread frappé when it’s chilly. (Mashable Senior Shopping Reporter Leah Stodart loves her Slushi, and so do all of her friends.) A year after the first Slushi came out, Ninja released two larger capacity versions in a few fun colors. The 88-ounce model on sale for $269.99 at Amazon can make a slightly bigger batch than the original 72-ounce model, which is on sale for $249.99 at Walmart. $20 more for extra beverages and a chic green build? Sold. (If you want the purple one, it’s $269.99 at Target.)

More Black Friday kitchen deals

Best outdoor deal

LifeStraw Personal Water Filter

$9.49
at Amazon

$19.95
Save $10.46

 

Why we like it

If there’s one thing Mashable readers love buying on Black Friday, it’s the LifeStraw. It’s a staple of every major sales event, and for good reason. Right now, it’s back down to its Prime Day price of $9.99, which is typically the lowest it goes all year (it’s usually around $20). Even if you aren’t an avid hiker, this is a must-have for your home emergency kit or bug-out bag. It filters out 99.999999 percent of waterborne bacteria and parasites, so you can drink directly from a stream (or a sketchy tap) safely. At $10, it’s the ultimate practical stocking stuffer.

More early Black Friday outdoor deals

Drones and action cameras

Other outdoor gear

Beauty tech deals

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published late last week in the journal Nature Microbiology.

Good guy prions?

Prions are some of the strangest things around. They’re the misfolded form of a protein naturally found in the body. When a prion comes across its “normal” counterpart, it can somehow induce the latter to turn into a prion itself, almost like a zombie infection.

Classic prion disorders like mad cow disease and Creutzfeldt-Jakob disease are caused by the steady accumulation of one particular type of protein, aptly named the prion protein; these disorders are universally fatal. Some scientists have also argued that other neurodegenerative conditions, such as Alzheimer’s disease, are caused by other kinds of misfolded proteins that act in a similar way to prions.

According to the study researchers, there’s growing evidence that prions and prion-like proteins are more than just harbingers of death. Studies have found that the normal prion protein and the prion-like amyloid beta (one of the drivers of Alzheimer’s) can have antimicrobial activity, for instance. So the team decided to conduct a sweeping analysis looking for antimicrobial peptide fragments within these proteins.

The researchers had previously built an AI model intended to predict the antimicrobial activity of any given peptide fragment, named APEX 1.1. Then they let APEX scan through 19.3 million short peptide fragments found in 2,897 prion and prion-like proteins. They initially uncovered 1,179 candidates, which the team narrowed down to 75 that showed the most potential. Of these, 59 were able to inhibit the growth of at least one bacterial germ in the lab, including 42 that did so at low levels (important for dosing considerations).

Finally, the researchers tested two of the strongest candidates on the skin of mice infected with Acinetobacter baumannii, a common source of drug-resistant infections in people. The candidates appeared to be roughly as effective as polymyxin B, an existing antibiotic often used as a last resort drug for certain drug-resistant infections.

The researchers have coined these antibacterial fragments collected from prions as “prionins.”

The future of prionins

More research is obviously needed to verify whether the team’s prionins can actually work as hoped—and safely—in people. The researchers also note their findings don’t settle the open question as to whether prions or prion-like proteins naturally tackle bacterial infections in our body.

At the same time, they do argue their work provides a strong proof of concept that prionins identified through AI can be viable antibiotic candidates for further testing.

“For a long time, drug discovery has been limited not only by what we can test, but by where we choose to look,” said senior study author César de la Fuente, director of the Machine Biology Group at the University of Pennsylvania Perelman School of Medicine, in a statement from the university. “AI is changing that. It gives us a way to search the hidden layers of biology and ask whether molecules associated with one story—in this case, disease—may also carry another story with therapeutic potential.”

With any luck, the proteins known for causing the scariest diseases around could someday turn into our antibacterial allies.

#Deadly #Proteins #Mad #Cow #Disease #Fight #Superbugsantibiotic resistance,experimental drugs,prions">Deadly Proteins Behind Mad Cow Disease Might Help Us Fight Superbugs
                The next frontier of antibiotics might come from an unexpected place. Recent research identifies potential antibiotic candidates from inside prions—proteins capable of causing some of the deadliest brain infections ever known, such as mad cow disease.

 Scientists at the University of Pennsylvania used artificial intelligence to rapidly search hundreds of prions and prion-like proteins for peptides with antibacterial activity. They found several dozen promising candidates, two of which have already shown results treating bacterial infections in mice. The team’s findings establish “prion-related proteins as a productive source space for antibiotic discovery,” the scientists wrote in their paper, published late last week in the journal Nature Microbiology.

 Good guy prions? Prions are some of the strangest things around. They’re the misfolded form of a protein naturally found in the body. When a prion comes across its “normal” counterpart, it can somehow induce the latter to turn into a prion itself, almost like a zombie infection.

 Classic prion disorders like mad cow disease and Creutzfeldt-Jakob disease are caused by the steady accumulation of one particular type of protein, aptly named the prion protein; these disorders are universally fatal. Some scientists have also argued that other neurodegenerative conditions, such as Alzheimer’s disease, are caused by other kinds of misfolded proteins that act in a similar way to prions.   According to the study researchers, there’s growing evidence that prions and prion-like proteins are more than just harbingers of death. Studies have found that the normal prion protein and the prion-like amyloid beta (one of the drivers of Alzheimer’s) can have antimicrobial activity, for instance. So the team decided to conduct a sweeping analysis looking for antimicrobial peptide fragments within these proteins.

 The researchers had previously built an AI model intended to predict the antimicrobial activity of any given peptide fragment, named APEX 1.1. Then they let APEX scan through 19.3 million short peptide fragments found in 2,897 prion and prion-like proteins. They initially uncovered 1,179 candidates, which the team narrowed down to 75 that showed the most potential. Of these, 59 were able to inhibit the growth of at least one bacterial germ in the lab, including 42 that did so at low levels (important for dosing considerations). Finally, the researchers tested two of the strongest candidates on the skin of mice infected with Acinetobacter baumannii, a common source of drug-resistant infections in people. The candidates appeared to be roughly as effective as polymyxin B, an existing antibiotic often used as a last resort drug for certain drug-resistant infections. The researchers have coined these antibacterial fragments collected from prions as “prionins.”

 The future of prionins More research is obviously needed to verify whether the team’s prionins can actually work as hoped—and safely—in people. The researchers also note their findings don’t settle the open question as to whether prions or prion-like proteins naturally tackle bacterial infections in our body. At the same time, they do argue their work provides a strong proof of concept that prionins identified through AI can be viable antibiotic candidates for further testing. “For a long time, drug discovery has been limited not only by what we can test, but by where we choose to look,” said senior study author César de la Fuente, director of the Machine Biology Group at the University of Pennsylvania Perelman School of Medicine, in a statement from the university. “AI is changing that. It gives us a way to search the hidden layers of biology and ask whether molecules associated with one story—in this case, disease—may also carry another story with therapeutic potential.”

 With any luck, the proteins known for causing the scariest diseases around could someday turn into our antibacterial allies.      #Deadly #Proteins #Mad #Cow #Disease #Fight #Superbugsantibiotic resistance,experimental drugs,prions

published late last week in the journal Nature Microbiology.

Good guy prions?

Prions are some of the strangest things around. They’re the misfolded form of a protein naturally found in the body. When a prion comes across its “normal” counterpart, it can somehow induce the latter to turn into a prion itself, almost like a zombie infection.

Classic prion disorders like mad cow disease and Creutzfeldt-Jakob disease are caused by the steady accumulation of one particular type of protein, aptly named the prion protein; these disorders are universally fatal. Some scientists have also argued that other neurodegenerative conditions, such as Alzheimer’s disease, are caused by other kinds of misfolded proteins that act in a similar way to prions.

According to the study researchers, there’s growing evidence that prions and prion-like proteins are more than just harbingers of death. Studies have found that the normal prion protein and the prion-like amyloid beta (one of the drivers of Alzheimer’s) can have antimicrobial activity, for instance. So the team decided to conduct a sweeping analysis looking for antimicrobial peptide fragments within these proteins.

The researchers had previously built an AI model intended to predict the antimicrobial activity of any given peptide fragment, named APEX 1.1. Then they let APEX scan through 19.3 million short peptide fragments found in 2,897 prion and prion-like proteins. They initially uncovered 1,179 candidates, which the team narrowed down to 75 that showed the most potential. Of these, 59 were able to inhibit the growth of at least one bacterial germ in the lab, including 42 that did so at low levels (important for dosing considerations).

Finally, the researchers tested two of the strongest candidates on the skin of mice infected with Acinetobacter baumannii, a common source of drug-resistant infections in people. The candidates appeared to be roughly as effective as polymyxin B, an existing antibiotic often used as a last resort drug for certain drug-resistant infections.

The researchers have coined these antibacterial fragments collected from prions as “prionins.”

The future of prionins

More research is obviously needed to verify whether the team’s prionins can actually work as hoped—and safely—in people. The researchers also note their findings don’t settle the open question as to whether prions or prion-like proteins naturally tackle bacterial infections in our body.

At the same time, they do argue their work provides a strong proof of concept that prionins identified through AI can be viable antibiotic candidates for further testing.

“For a long time, drug discovery has been limited not only by what we can test, but by where we choose to look,” said senior study author César de la Fuente, director of the Machine Biology Group at the University of Pennsylvania Perelman School of Medicine, in a statement from the university. “AI is changing that. It gives us a way to search the hidden layers of biology and ask whether molecules associated with one story—in this case, disease—may also carry another story with therapeutic potential.”

With any luck, the proteins known for causing the scariest diseases around could someday turn into our antibacterial allies.

#Deadly #Proteins #Mad #Cow #Disease #Fight #Superbugsantibiotic resistance,experimental drugs,prions">Deadly Proteins Behind Mad Cow Disease Might Help Us Fight SuperbugsDeadly Proteins Behind Mad Cow Disease Might Help Us Fight Superbugs
                The next frontier of antibiotics might come from an unexpected place. Recent research identifies potential antibiotic candidates from inside prions—proteins capable of causing some of the deadliest brain infections ever known, such as mad cow disease.

 Scientists at the University of Pennsylvania used artificial intelligence to rapidly search hundreds of prions and prion-like proteins for peptides with antibacterial activity. They found several dozen promising candidates, two of which have already shown results treating bacterial infections in mice. The team’s findings establish “prion-related proteins as a productive source space for antibiotic discovery,” the scientists wrote in their paper, published late last week in the journal Nature Microbiology.

 Good guy prions? Prions are some of the strangest things around. They’re the misfolded form of a protein naturally found in the body. When a prion comes across its “normal” counterpart, it can somehow induce the latter to turn into a prion itself, almost like a zombie infection.

 Classic prion disorders like mad cow disease and Creutzfeldt-Jakob disease are caused by the steady accumulation of one particular type of protein, aptly named the prion protein; these disorders are universally fatal. Some scientists have also argued that other neurodegenerative conditions, such as Alzheimer’s disease, are caused by other kinds of misfolded proteins that act in a similar way to prions.   According to the study researchers, there’s growing evidence that prions and prion-like proteins are more than just harbingers of death. Studies have found that the normal prion protein and the prion-like amyloid beta (one of the drivers of Alzheimer’s) can have antimicrobial activity, for instance. So the team decided to conduct a sweeping analysis looking for antimicrobial peptide fragments within these proteins.

 The researchers had previously built an AI model intended to predict the antimicrobial activity of any given peptide fragment, named APEX 1.1. Then they let APEX scan through 19.3 million short peptide fragments found in 2,897 prion and prion-like proteins. They initially uncovered 1,179 candidates, which the team narrowed down to 75 that showed the most potential. Of these, 59 were able to inhibit the growth of at least one bacterial germ in the lab, including 42 that did so at low levels (important for dosing considerations). Finally, the researchers tested two of the strongest candidates on the skin of mice infected with Acinetobacter baumannii, a common source of drug-resistant infections in people. The candidates appeared to be roughly as effective as polymyxin B, an existing antibiotic often used as a last resort drug for certain drug-resistant infections. The researchers have coined these antibacterial fragments collected from prions as “prionins.”

 The future of prionins More research is obviously needed to verify whether the team’s prionins can actually work as hoped—and safely—in people. The researchers also note their findings don’t settle the open question as to whether prions or prion-like proteins naturally tackle bacterial infections in our body. At the same time, they do argue their work provides a strong proof of concept that prionins identified through AI can be viable antibiotic candidates for further testing. “For a long time, drug discovery has been limited not only by what we can test, but by where we choose to look,” said senior study author César de la Fuente, director of the Machine Biology Group at the University of Pennsylvania Perelman School of Medicine, in a statement from the university. “AI is changing that. It gives us a way to search the hidden layers of biology and ask whether molecules associated with one story—in this case, disease—may also carry another story with therapeutic potential.”

 With any luck, the proteins known for causing the scariest diseases around could someday turn into our antibacterial allies.      #Deadly #Proteins #Mad #Cow #Disease #Fight #Superbugsantibiotic resistance,experimental drugs,prions

The next frontier of antibiotics might come from an unexpected place. Recent research identifies potential antibiotic candidates from inside prions—proteins capable of causing some of the deadliest brain infections ever known, such as mad cow disease.

Scientists at the University of Pennsylvania used artificial intelligence to rapidly search hundreds of prions and prion-like proteins for peptides with antibacterial activity. They found several dozen promising candidates, two of which have already shown results treating bacterial infections in mice.

The team’s findings establish “prion-related proteins as a productive source space for antibiotic discovery,” the scientists wrote in their paper, published late last week in the journal Nature Microbiology.

Good guy prions?

Prions are some of the strangest things around. They’re the misfolded form of a protein naturally found in the body. When a prion comes across its “normal” counterpart, it can somehow induce the latter to turn into a prion itself, almost like a zombie infection.

Classic prion disorders like mad cow disease and Creutzfeldt-Jakob disease are caused by the steady accumulation of one particular type of protein, aptly named the prion protein; these disorders are universally fatal. Some scientists have also argued that other neurodegenerative conditions, such as Alzheimer’s disease, are caused by other kinds of misfolded proteins that act in a similar way to prions.

According to the study researchers, there’s growing evidence that prions and prion-like proteins are more than just harbingers of death. Studies have found that the normal prion protein and the prion-like amyloid beta (one of the drivers of Alzheimer’s) can have antimicrobial activity, for instance. So the team decided to conduct a sweeping analysis looking for antimicrobial peptide fragments within these proteins.

The researchers had previously built an AI model intended to predict the antimicrobial activity of any given peptide fragment, named APEX 1.1. Then they let APEX scan through 19.3 million short peptide fragments found in 2,897 prion and prion-like proteins. They initially uncovered 1,179 candidates, which the team narrowed down to 75 that showed the most potential. Of these, 59 were able to inhibit the growth of at least one bacterial germ in the lab, including 42 that did so at low levels (important for dosing considerations).

Finally, the researchers tested two of the strongest candidates on the skin of mice infected with Acinetobacter baumannii, a common source of drug-resistant infections in people. The candidates appeared to be roughly as effective as polymyxin B, an existing antibiotic often used as a last resort drug for certain drug-resistant infections.

The researchers have coined these antibacterial fragments collected from prions as “prionins.”

The future of prionins

More research is obviously needed to verify whether the team’s prionins can actually work as hoped—and safely—in people. The researchers also note their findings don’t settle the open question as to whether prions or prion-like proteins naturally tackle bacterial infections in our body.

At the same time, they do argue their work provides a strong proof of concept that prionins identified through AI can be viable antibiotic candidates for further testing.

“For a long time, drug discovery has been limited not only by what we can test, but by where we choose to look,” said senior study author César de la Fuente, director of the Machine Biology Group at the University of Pennsylvania Perelman School of Medicine, in a statement from the university. “AI is changing that. It gives us a way to search the hidden layers of biology and ask whether molecules associated with one story—in this case, disease—may also carry another story with therapeutic potential.”

With any luck, the proteins known for causing the scariest diseases around could someday turn into our antibacterial allies.

#Deadly #Proteins #Mad #Cow #Disease #Fight #Superbugsantibiotic resistance,experimental drugs,prions

PS Svarva Floor Lamp

“Some stuff I did myself, like this one. The Svarva lamp we made with the design group Front for the PS 2009 collection. They were quite newly established and so we did an armchair and this lamp. The desire was to do a wooden turned lamp, but you should also be able to twist it, articulate it.”

“I felt that that would be very difficult to do. Along with a colleague in lighting at the time, I went to Hungary to this factory that was producing lamps for us. It was all metal tubes that they were doing, so we were a little bit hesitant whether they should be able to solve this. But they made some mock-ups based on the designer drawings. So we went there to have a look, and it was standing there. It was this floor lamp, and also a table lamp where the wooden beads were going in a circle and then up, like a snake.”

“What we didn’t know was that next to the lamp factory was this factory that was doing the turned wooden beads, the small individual pieces that we put together. None of us knew that. It was just pure serendipity. So they were turning these wooden beads, and the lamp factory was putting them on the metal tubes, just like on a necklace. They had very little to do, so they were happy to get the business.”

Image may contain Furniture Home Decor Rug Clothing Footwear Shoe and Chest Of Drawers

A Sinka Cabinet resides in Ejdemo’s hallway.

Courtesy of Johan Ejdemo

PS Sinka Cabinet

“I have another favorite from that PS 2009 collection, it’s in my hallway. The PS Sinka, with the small drawers with a wooden base. Sinka means “dovetail” in Swedish, so the name explaining that construction.”

“But the problem we had with this one was the packaging volume was too big. So what we did was each drawer is slightly shallower. So four drawers stack into each other. And four more drawers stack. There’s a little bit of a stopper in the back when you push them in, so they stop evenly at the front. There’s also a hidden compartment behind the smallest drawer. Really good drawers for all this stuff that is just lying around and getting in the way. In the top one I have all my keys that I no longer know where they go.”

PS Jonsberg Vases

“I have this vase from the PS collection to hold the cables [on my Samsung Serif TV]. It was a set, the Jonsberg vases by Hella Jongerius. There were four of them in different ceramic techniques. I had all four, but the terracotta one broke, which was a pity.” [It certainly is. These $39 vases now sell secondhand for $1,700 for a full set.]

“They’re inspired by different regions, and the different techniques are beautiful. I use the big black one for toilet paper in one bathroom. It’s not disrespect for the design. It’s just such a good design to stand there, and it makes the bathroom beautiful, and it can fit the toilet roll. So, why have something like an ugly stick? It’s nice for that.”

Pax Wardrobes

“Pax. We have to mention Pax. I have Pax wardrobes in a few rooms, but also I’m a little bit peculiar. Like in the kitchen, these veneer doors have been sanded and hand-painted by me, just to make them fit my house, in my space. I repaint them sometimes.”

Chipped Spraka pepper mills.

Chipped Spraka pepper mills.

Courtesy of Johan Ejdemo

Spraka Pepper Mills

“I have these pepper mills. One for white pepper, one for black pepper. That was also in a PS collection. We did these with Marcus Arvonen. These pepper mills are beautiful, and these have been around for, like, 20 years as well. They are pretty tall. A smaller version came later on, but I like these.”

“They have their chips, yes, but this just makes them nicer. It’s age. They’ve been around and are used every day. Everything has a little bit of imperfection. You can spend your whole life bothering about that, but there should be some imperfection in life. Fix it? Then something else needs fixing. It just moves. Leave it, be proud.”

Where’s the Billy Bookcase or Kallax?

“I don’t have a Billy in the house now. But there have been! Kallax? I have owned many. Brilliant piece. Really good for vinyl, because that’s the time they come from. I listen to a lot of vinyl.”

#Ikea #Products #Companys #Design #Chief #Personally #Ownsikea,design,home,furniture,household,interviews">These Are the 12 Ikea Products the Company’s Design Chief Personally OwnsThe Svarva lamp can be twisted into different shapes.
Courtesy of Johan EjdemoPS Svarva Floor Lamp“Some stuff I did myself, like this one. The Svarva lamp we made with the design group Front for the PS 2009 collection. They were quite newly established and so we did an armchair and this lamp. The desire was to do a wooden turned lamp, but you should also be able to twist it, articulate it.”“I felt that that would be very difficult to do. Along with a colleague in lighting at the time, I went to Hungary to this factory that was producing lamps for us. It was all metal tubes that they were doing, so we were a little bit hesitant whether they should be able to solve this. But they made some mock-ups based on the designer drawings. So we went there to have a look, and it was standing there. It was this floor lamp, and also a table lamp where the wooden beads were going in a circle and then up, like a snake.”“What we didn’t know was that next to the lamp factory was this factory that was doing the turned wooden beads, the small individual pieces that we put together. None of us knew that. It was just pure serendipity. So they were turning these wooden beads, and the lamp factory was putting them on the metal tubes, just like on a necklace. They had very little to do, so they were happy to get the business.”A Sinka Cabinet resides in Ejdemo’s hallway.
Courtesy of Johan EjdemoPS Sinka Cabinet“I have another favorite from that PS 2009 collection, it’s in my hallway. The PS Sinka, with the small drawers with a wooden base. Sinka means “dovetail” in Swedish, so the name explaining that construction.”“But the problem we had with this one was the packaging volume was too big. So what we did was each drawer is slightly shallower. So four drawers stack into each other. And four more drawers stack. There’s a little bit of a stopper in the back when you push them in, so they stop evenly at the front. There’s also a hidden compartment behind the smallest drawer. Really good drawers for all this stuff that is just lying around and getting in the way. In the top one I have all my keys that I no longer know where they go.”PS Jonsberg Vases“I have this vase from the PS collection to hold the cables [on my Samsung Serif TV]. It was a set, the Jonsberg vases by Hella Jongerius. There were four of them in different ceramic techniques. I had all four, but the terracotta one broke, which was a pity.” [It certainly is. These  vases now sell secondhand for ,700 for a full set.]“They’re inspired by different regions, and the different techniques are beautiful. I use the big black one for toilet paper in one bathroom. It’s not disrespect for the design. It’s just such a good design to stand there, and it makes the bathroom beautiful, and it can fit the toilet roll. So, why have something like an ugly stick? It’s nice for that.”Pax Wardrobes“Pax. We have to mention Pax. I have Pax wardrobes in a few rooms, but also I’m a little bit peculiar. Like in the kitchen, these veneer doors have been sanded and hand-painted by me, just to make them fit my house, in my space. I repaint them sometimes.”Chipped Spraka pepper mills.
Courtesy of Johan EjdemoSpraka Pepper Mills“I have these pepper mills. One for white pepper, one for black pepper. That was also in a PS collection. We did these with Marcus Arvonen. These pepper mills are beautiful, and these have been around for, like, 20 years as well. They are pretty tall. A smaller version came later on, but I like these.”“They have their chips, yes, but this just makes them nicer. It’s age. They’ve been around and are used every day. Everything has a little bit of imperfection. You can spend your whole life bothering about that, but there should be some imperfection in life. Fix it? Then something else needs fixing. It just moves. Leave it, be proud.”Where’s the Billy Bookcase or Kallax?“I don’t have a Billy in the house now. But there have been! Kallax? I have owned many. Brilliant piece. Really good for vinyl, because that’s the time they come from. I listen to a lot of vinyl.”#Ikea #Products #Companys #Design #Chief #Personally #Ownsikea,design,home,furniture,household,interviews

Svarva lamp we made with the design group Front for the PS 2009 collection. They were quite newly established and so we did an armchair and this lamp. The desire was to do a wooden turned lamp, but you should also be able to twist it, articulate it.”

“I felt that that would be very difficult to do. Along with a colleague in lighting at the time, I went to Hungary to this factory that was producing lamps for us. It was all metal tubes that they were doing, so we were a little bit hesitant whether they should be able to solve this. But they made some mock-ups based on the designer drawings. So we went there to have a look, and it was standing there. It was this floor lamp, and also a table lamp where the wooden beads were going in a circle and then up, like a snake.”

“What we didn’t know was that next to the lamp factory was this factory that was doing the turned wooden beads, the small individual pieces that we put together. None of us knew that. It was just pure serendipity. So they were turning these wooden beads, and the lamp factory was putting them on the metal tubes, just like on a necklace. They had very little to do, so they were happy to get the business.”

Image may contain Furniture Home Decor Rug Clothing Footwear Shoe and Chest Of Drawers

A Sinka Cabinet resides in Ejdemo’s hallway.

Courtesy of Johan Ejdemo

PS Sinka Cabinet

“I have another favorite from that PS 2009 collection, it’s in my hallway. The PS Sinka, with the small drawers with a wooden base. Sinka means “dovetail” in Swedish, so the name explaining that construction.”

“But the problem we had with this one was the packaging volume was too big. So what we did was each drawer is slightly shallower. So four drawers stack into each other. And four more drawers stack. There’s a little bit of a stopper in the back when you push them in, so they stop evenly at the front. There’s also a hidden compartment behind the smallest drawer. Really good drawers for all this stuff that is just lying around and getting in the way. In the top one I have all my keys that I no longer know where they go.”

PS Jonsberg Vases

“I have this vase from the PS collection to hold the cables [on my Samsung Serif TV]. It was a set, the Jonsberg vases by Hella Jongerius. There were four of them in different ceramic techniques. I had all four, but the terracotta one broke, which was a pity.” [It certainly is. These $39 vases now sell secondhand for $1,700 for a full set.]

“They’re inspired by different regions, and the different techniques are beautiful. I use the big black one for toilet paper in one bathroom. It’s not disrespect for the design. It’s just such a good design to stand there, and it makes the bathroom beautiful, and it can fit the toilet roll. So, why have something like an ugly stick? It’s nice for that.”

Pax Wardrobes

“Pax. We have to mention Pax. I have Pax wardrobes in a few rooms, but also I’m a little bit peculiar. Like in the kitchen, these veneer doors have been sanded and hand-painted by me, just to make them fit my house, in my space. I repaint them sometimes.”

Chipped Spraka pepper mills.

Chipped Spraka pepper mills.

Courtesy of Johan Ejdemo

Spraka Pepper Mills

“I have these pepper mills. One for white pepper, one for black pepper. That was also in a PS collection. We did these with Marcus Arvonen. These pepper mills are beautiful, and these have been around for, like, 20 years as well. They are pretty tall. A smaller version came later on, but I like these.”

“They have their chips, yes, but this just makes them nicer. It’s age. They’ve been around and are used every day. Everything has a little bit of imperfection. You can spend your whole life bothering about that, but there should be some imperfection in life. Fix it? Then something else needs fixing. It just moves. Leave it, be proud.”

Where’s the Billy Bookcase or Kallax?

“I don’t have a Billy in the house now. But there have been! Kallax? I have owned many. Brilliant piece. Really good for vinyl, because that’s the time they come from. I listen to a lot of vinyl.”

#Ikea #Products #Companys #Design #Chief #Personally #Ownsikea,design,home,furniture,household,interviews">These Are the 12 Ikea Products the Company’s Design Chief Personally Owns
Image may contain Lamp Chair Furniture Art Painting and Floor Lamp

The Svarva lamp can be twisted into different shapes.

Courtesy of Johan Ejdemo

PS Svarva Floor Lamp

“Some stuff I did myself, like this one. The Svarva lamp we made with the design group Front for the PS 2009 collection. They were quite newly established and so we did an armchair and this lamp. The desire was to do a wooden turned lamp, but you should also be able to twist it, articulate it.”

“I felt that that would be very difficult to do. Along with a colleague in lighting at the time, I went to Hungary to this factory that was producing lamps for us. It was all metal tubes that they were doing, so we were a little bit hesitant whether they should be able to solve this. But they made some mock-ups based on the designer drawings. So we went there to have a look, and it was standing there. It was this floor lamp, and also a table lamp where the wooden beads were going in a circle and then up, like a snake.”

“What we didn’t know was that next to the lamp factory was this factory that was doing the turned wooden beads, the small individual pieces that we put together. None of us knew that. It was just pure serendipity. So they were turning these wooden beads, and the lamp factory was putting them on the metal tubes, just like on a necklace. They had very little to do, so they were happy to get the business.”

Image may contain Furniture Home Decor Rug Clothing Footwear Shoe and Chest Of Drawers

A Sinka Cabinet resides in Ejdemo’s hallway.

Courtesy of Johan Ejdemo

PS Sinka Cabinet

“I have another favorite from that PS 2009 collection, it’s in my hallway. The PS Sinka, with the small drawers with a wooden base. Sinka means “dovetail” in Swedish, so the name explaining that construction.”

“But the problem we had with this one was the packaging volume was too big. So what we did was each drawer is slightly shallower. So four drawers stack into each other. And four more drawers stack. There’s a little bit of a stopper in the back when you push them in, so they stop evenly at the front. There’s also a hidden compartment behind the smallest drawer. Really good drawers for all this stuff that is just lying around and getting in the way. In the top one I have all my keys that I no longer know where they go.”

PS Jonsberg Vases

“I have this vase from the PS collection to hold the cables [on my Samsung Serif TV]. It was a set, the Jonsberg vases by Hella Jongerius. There were four of them in different ceramic techniques. I had all four, but the terracotta one broke, which was a pity.” [It certainly is. These $39 vases now sell secondhand for $1,700 for a full set.]

“They’re inspired by different regions, and the different techniques are beautiful. I use the big black one for toilet paper in one bathroom. It’s not disrespect for the design. It’s just such a good design to stand there, and it makes the bathroom beautiful, and it can fit the toilet roll. So, why have something like an ugly stick? It’s nice for that.”

Pax Wardrobes

“Pax. We have to mention Pax. I have Pax wardrobes in a few rooms, but also I’m a little bit peculiar. Like in the kitchen, these veneer doors have been sanded and hand-painted by me, just to make them fit my house, in my space. I repaint them sometimes.”

Chipped Spraka pepper mills.

Chipped Spraka pepper mills.

Courtesy of Johan Ejdemo

Spraka Pepper Mills

“I have these pepper mills. One for white pepper, one for black pepper. That was also in a PS collection. We did these with Marcus Arvonen. These pepper mills are beautiful, and these have been around for, like, 20 years as well. They are pretty tall. A smaller version came later on, but I like these.”

“They have their chips, yes, but this just makes them nicer. It’s age. They’ve been around and are used every day. Everything has a little bit of imperfection. You can spend your whole life bothering about that, but there should be some imperfection in life. Fix it? Then something else needs fixing. It just moves. Leave it, be proud.”

Where’s the Billy Bookcase or Kallax?

“I don’t have a Billy in the house now. But there have been! Kallax? I have owned many. Brilliant piece. Really good for vinyl, because that’s the time they come from. I listen to a lot of vinyl.”

#Ikea #Products #Companys #Design #Chief #Personally #Ownsikea,design,home,furniture,household,interviews

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