Week 10 of the 2025 NFL season kicks off tonight with an AFC West rivalry featuring the Las Vegas Raiders visiting the Denver Broncos. Denver enters as a 9.5-point home favorite, with an over/under of 42.5. The Broncos are looking to maintain their lead atop the division while the Raiders are looking to bounce back after falling short in their overtime loss to the Jaguars this past Sunday.

Below, we will take a look at the best DFS plays for this Thursday night showdown.

Bo Nix, QB, Denver Broncos (FLEX $13,800, CPT $20,700)

It hasn’t always been pretty, but Nix has been getting the job done this season and has a chance to run the Broncos’ win streak up to seven this evening. The second-year quarterback is averaging roughly 21 fantasy points per game in DFS and his 17 passing touchdowns is tied for the third most in the league heading into Week 10. That can be attributed to his sheer volume of throws as he ranks sixth in the NFL with 35.8 pass attempts per game.

Nix’s running ability has also boosted his fantasy value this season as he is one of just nine QB’s with over 200 rushing yards for the year. The Raiders are a middle of the road team when it comes to defending the run against opposing QB’s this season, so there is a chance that the Broncos’ signal-caller could get loose on a few plays tonight.

Brock Bowers, TE, Las Vegas Raiders (FLEX $12,000, CPT $18,000)

Oh hey, Bowers is back from his knee injury and he casually caught 12 targets for 127 yards and three touchdowns in the Raiders’ overtime loss to the Jaguars on Sunday. No big deal. After a month-long hiatus, the second-year All-Pro just casually resumed his dominance upon his return and gave an immediately jolt to the Raiders offense. And with the team dealing Jakobi Meyers ahead of Tuesday’s trade deadline, he may be in line for even more targets.

Yeah, Bowers as a potential captain’s option is a no-brainer here, even against a tough Denver defense.

J.K. Dobbins, RB, Denver Broncos (FLEX $10,600, CPT $15,900)

Dobbins has been a central figure of the Broncos’ offense all season long and contributed 61 rushing yards in their 18-15 victory over the Texans this past Sunday. The veteran back has just been all around solid and enters tonight’s matchup ranked sixth in the NFL in total carries with 135 and fifth in the NFL in rushing yards with 695.

He’s certainly making good use of all the touches he gets every week as he ranks in the top 10 in metrics like rushing EPA, yards per carry, success rate, and explosive run rate. That means you’re more often than not in good hands with Dobbins in your lineup and he’s worthy of captain consideration.

R.J. Harvey, RB, Denver Broncos (FLEX $7,600, CPT $11,400)

While Dobbins is getting most of the work out of the backfield for the Broncos, Harvey is starting carve out of a role for himself as his backup. He punched in two touchdowns in their win against the Cowboys two weeks ago and then turned five receptions into 51 yards and a touchdown against the Texans this past Sunday. The rookie is heating up and he’ll most likely get plenty of touches once again tonight.

Denver Broncos Defense (FLEX $6,800, CPT $10,200)

The Broncos’ defense has been wreaking havoc all season and enters Week 10 leading the league in sacks with 40 while yielding just 18.4 points per game. Tonight, they have a chance to really get after Raiders QB Geno Smith, who is tied for the most interceptions in the NFL this season with 11 and has a high sack rate of 7.8%. Denver can definitely come away with a turnover or two in this one.

Michael Mayer, TE, Las Vegas Raiders (FLEX $4,600, CPT $6,900)

Just because Bowers is back doesn’t mean that Mayer can’t eat as well. The Raiders No. 2 tight end is just a few weeks removed from his 50-yard, one-touchdown performance against the Titans and still got seven targets even with Bowers back in the lineup this past Sunday. And with Jakobi Meyers now gone to Jacksonville, there’s a chance that Mayer could get more looks in the coming weeks. Don’t sleep on him.