For people with diabetes, high blood sugar can damage blood vessels and nerves, leading to chronic wounds that stay open for months. But a new gel-based treatment could massively speed up the healing process for people with diabetes, allowing wounds to close in just days, according to a new study.
The new treatment targets thrombospondin-1 (TSP-1), a protein that inhibits the growth of new blood vessels, a crucial step in the healing process. Targeting this protein increased new blood vessel formation in human endothelial cells and in diabetic mouse models, leading to a remarkable wound closure rate in less than two weeks. A team of researchers from various institutes in China unveiled the new technology in a study published in the journal Burns & Trauma.
“Our results demonstrate the power of combining advanced tissue engineering with molecular biology. By targeting TSP-1 with miR-221OE-sEVs encapsulated in GelMA, we’ve not only improved endothelial cell function but also ensured a sustained and localized therapeutic effect,” Chuan’an Shen, a researcher at The Fourth Medical Center of Chinese PLA General Hospital, said in a statement.
Diabetic wounds have increased levels of TSP-1 in endothelial cells, the cells that line blood vessels, according to previous studies. TSP-1 hinders their ability to divide and go where they need to go. The study researchers developed a way to decrease levels of TSP-1.
The technology uses small extracellular vesicles (sEVs)—teeny membrane-bound sacs usually released by cells—loaded with miR-221-3p, a microRNA that disrupts the production of TSP-1 in endothelial cells.
The researchers encapsulated these sEVs in a hydrogel, which mimics the extracellular environment and provides a sustained, controlled release of miR-221-3p at the wound site. In diabetic mouse models, the gel significantly accelerated healing, leading to a 90% wound closure rate within 12 days—compared to just 20% in untreated mice over the same period.
The next steps are to bring the new gel into clinical trials, according to the authors. “This breakthrough could revolutionize how we approach diabetic wound care, with the potential to improve patients’ quality of life significantly,” Shen said in a statement.
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#Gel #Heal #Stubborn #Diabetic #Wounds #Weeks
![Exclusive: Redwood Materials lays off 10% in restructuring to chase energy storage business | TechCrunch
Redwood Materials has laid off around 135 employees, or roughly 10% of its workforce, as it restructures to better accommodate its growing energy storage business, TechCrunch has learned.
The cuts come just five months after Redwood cut 5% of its workforce, and three months after it closed a 5 million funding round that boosted the battery recycling company’s valuation to north of billion, as TechCrunch previously reported.
It’s been a difficult time in the battery industry lately. Earlier this month, battery recycler Ascend Elements filed for Chapter 11 bankruptcy protection, citing “insurmountable” financial challenges. Some battery-makers have also restructured or gone out of business as the automotive industry in the U.S. has backed away from its most optimistic and ambitious plans to transition to electric vehicles.
But Redwood Materials founder and CEO JB Straubel told employees that this new round of cuts is not a sign that the company is heading down the same path.
“Redwood today is the strongest it’s ever been,” Straubel wrote in an email to the workers who weren’t laid off, according to a copy viewed by TechCrunch. “The materials business is well on its way to profitability and has an exciting roadmap ahead.”
Straubel noted that Redwood “continue[s] to dominate the US battery recycling market” but also touted the company’s “great momentum” in its new energy storage business. Redwood has recently announced deals with Crusoe AI and, most recently, electric automaker Rivian to provide recycled batteries that can be used to power those companies’ facilities. The company declined to comment beyond the contents of Straubel’s email.
In his message, Straubel wrote that “parts of the company have expanded faster than needed to support the direction” of Redwood. As a result, he said Redwood is making cuts across multiple divisions, including the engineering and operations organizations, according to an employee who was granted anonymity to discuss the layoffs.
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San Francisco, CA
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October 13-15, 2026
“We are confident that we can deliver on our critical projects with a smaller team that is more focused,” he wrote. “We have successfully adapted to changes in the market that have bankrupted many of our competitors.”
Straubel went on to write that he is “more excited than ever with our path ahead as we build the most integrated and cost-effective critical materials and energy storage business in the world.”
“This is a self-sustaining business and will continue to make this company more valuable over time. We have the team and the technology to do what no other company can,” he wrote.
Workers who were laid off were told by Redwood’s chief HR officer that the layoffs were made “to sharpen our focus, our work and the size of our teams to support the direction Redwood is going in the future,” according to a copy of her email, which was viewed by TechCrunch.
Employees who were laid off are receiving severance and paid health benefits, according to Straubel’s email, as well as “career transition assistance.”
“I am grateful to the approximately 135 employees who we say goodbye to today — they’ve all contributed to building Redwood,” he wrote.
When you purchase through links in our articles, we may earn a small commission. This doesn’t affect our editorial independence.#Exclusive #Redwood #Materials #lays #restructuring #chase #energy #storage #business #TechCrunchBatteries,battery recycling,electric vehicles,EVs,Exclusive,Redwood Materials](https://i1.wp.com/techcrunch.com/wp-content/uploads/2023/09/53200897797_87d290a75e_o.jpg?resize=1200%2C800&ssl=1 "Exclusive: Redwood Materials lays off 10% in restructuring to chase energy storage business | TechCrunch
Redwood Materials has laid off around 135 employees, or roughly 10% of its workforce, as it restructures to better accommodate its growing energy storage business, TechCrunch has learned.
The cuts come just five months after Redwood cut 5% of its workforce, and three months after it closed a 5 million funding round that boosted the battery recycling company’s valuation to north of billion, as TechCrunch previously reported.
It’s been a difficult time in the battery industry lately. Earlier this month, battery recycler Ascend Elements filed for Chapter 11 bankruptcy protection, citing “insurmountable” financial challenges. Some battery-makers have also restructured or gone out of business as the automotive industry in the U.S. has backed away from its most optimistic and ambitious plans to transition to electric vehicles.
But Redwood Materials founder and CEO JB Straubel told employees that this new round of cuts is not a sign that the company is heading down the same path.
“Redwood today is the strongest it’s ever been,” Straubel wrote in an email to the workers who weren’t laid off, according to a copy viewed by TechCrunch. “The materials business is well on its way to profitability and has an exciting roadmap ahead.”
Straubel noted that Redwood “continue[s] to dominate the US battery recycling market” but also touted the company’s “great momentum” in its new energy storage business. Redwood has recently announced deals with Crusoe AI and, most recently, electric automaker Rivian to provide recycled batteries that can be used to power those companies’ facilities. The company declined to comment beyond the contents of Straubel’s email.
In his message, Straubel wrote that “parts of the company have expanded faster than needed to support the direction” of Redwood. As a result, he said Redwood is making cuts across multiple divisions, including the engineering and operations organizations, according to an employee who was granted anonymity to discuss the layoffs.
Techcrunch event
San Francisco, CA
|
October 13-15, 2026
“We are confident that we can deliver on our critical projects with a smaller team that is more focused,” he wrote. “We have successfully adapted to changes in the market that have bankrupted many of our competitors.”
Straubel went on to write that he is “more excited than ever with our path ahead as we build the most integrated and cost-effective critical materials and energy storage business in the world.”
“This is a self-sustaining business and will continue to make this company more valuable over time. We have the team and the technology to do what no other company can,” he wrote.
Workers who were laid off were told by Redwood’s chief HR officer that the layoffs were made “to sharpen our focus, our work and the size of our teams to support the direction Redwood is going in the future,” according to a copy of her email, which was viewed by TechCrunch.
Employees who were laid off are receiving severance and paid health benefits, according to Straubel’s email, as well as “career transition assistance.”
“I am grateful to the approximately 135 employees who we say goodbye to today — they’ve all contributed to building Redwood,” he wrote.
When you purchase through links in our articles, we may earn a small commission. This doesn’t affect our editorial independence.#Exclusive #Redwood #Materials #lays #restructuring #chase #energy #storage #business #TechCrunchBatteries,battery recycling,electric vehicles,EVs,Exclusive,Redwood Materials")
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