Patrick Dempsey is a Hitman with Alzheimer’s in ‘Memory of a Killer’

by Alex Billington
December 30, 2025
Source: YouTube

“Doesn’t he seem a little off lately?” Fox has revealed the full official trailer for a new hitman thriller series title Memory of a Killer, set to launch on TV starting in January 2026. We’re featuring this trailer for a TV show because it’s yet another new series that’s actually based on a movie. Inspired by the 2003 award-winning Belgian film De Zaak Alzheimer (also called The Memory of a Killer), Fox’s Memory of a Killer series is a dramatic thriller about a hitman with early onset Alzheimer’s. This stars Patrick Dempsey as Angelo, Michael Imperioli, Odeya Rush, Richard Harmon, Daniel David Stewart, Peter Gadiot, and Gina Torres. Angelo lives a double life as an assassin and a family man – which all worked out well until he was hit with early onset Alzheimer’s. Now his worlds are colliding, putting his family in danger. He must stop whoever’s coming for his family by searching his past hits for clues, and the list is very long. He’ll hunt down his mortal enemy while carrying out hits without giving away his diagnosis and still making it home in time to cook dinner. Memory of a Killer is a redemptive story about a man losing his memory but gaining a conscience. This seems extra mopey and melodramatic, but hopefully it’s a bit better than it looks.

Here’s the main official trailer (+ poster) for Fox’s series Memory of a Killer, direct from YouTube:

Losing one’s memory is a devastating hammer blow for anyone, but for Angelo Ledda, the stakes couldn’t be higher. His hit man job would be perilous enough, but there’s an added pressure: Angelo lives two totally separate lives — fearsome NYC hitman, and sleepy upstate Cooperstown photocopier salesman and father. Having built and maintained a brick wall between his two worlds, Angelo has seamlessly juggled and compartmentalized for years. But now that’s all about to change, because Alzheimer’s is a foe he can’t outrun, and he knows too well how this ends, as his older brother is already lost to the condition. Memory of a Killer is a series created by Ed Whitmore and Tracey Malone. With writing by Glenise Mullins, Tracey Malone, Ed Whitmore. Inspired by the Belgian film The Memory of a Killer (De Zaak Alzheimer) by Erik Van Looy. With episodes directed by David Petrarca, Toa Fraser, John Fawcett, Daniel Minahan, Martin Campbell. Made by Warner Bros. Television & Fox Entertainment. Executive produced by Martin Campbell, Tracey Malone, Kate Roughan, Arthur Sarkissian, Cathy Schulman, Andrea Shay, Ed Whitmore. Fox will debut the Memory of a Killer series airing on Fox TV starting January 25th, 2026 coming soon. Who in?

Find more posts in: Streaming, To Watch, Trailer